This proposal is driven by the need to find genes that contribute to the etiology of mental disorders;a goal more readily attained if clinical data and biological materials (DNA and cell lines) are openly shared among investigators. During the past four years, the NIMH Center for Genetic Studies (NCGS), established over 13,000 lymphoblast cell lines (LCLs) from blood samples and processed clinical and genotype data submitted by PIs of the NIMH Human Genetics Initiative. The NCGS distributed over 20,000 DNA aliquots and made more than 82 distributions of family, clinical and genotype data to a larger group of investigators. The establishment of these resources has played a critical role in enhancing and invigorating research on the genetics of mental disorders. Drs. Tischfield and Rice propose to continue their NCGS efforts with this application to become the Cooperative Agreement Award-funded (U24) """"""""Center for Collaborative Genetic Studies on Mental Disorders"""""""" (the """"""""Center""""""""), submitted in response to RFA MH-03-003. They will continue to produce LCLs as a renewable source of DNA and will maintain an improved and easily accessible, web-based bioinformatics repository of clinical and genotype data that will drive future research. They also propose analyses of shared, public data sets that will add to their predictive value for gene discovery. The Center will provide consultation on project design (e.g., power studies), detailed genomics of candidate regions, blood (or other biologicals) collection, data analysis, and best organization and use of shared resources. The overriding aim of the Center will be to serve the scientific needs of the NIMH PIs, while respecting subject confidentiality, informed consent issues, and PI prerogatives. By encouraging and facilitating the collection and sharing of biologicals as well as clinical and genotype data from subjects or families with mental disorders such as schizophrenia, bipolar disorder, or autism, and its own analyses of these data, the Center will greatly accelerate progress toward understanding the inherited components in the etiology of these diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24MH068457-10S1
Application #
8533570
Study Section
Special Emphasis Panel (ZMH1-ERB-C (07))
Program Officer
Panchision, David M
Project Start
2003-07-01
Project End
2013-05-31
Budget Start
2012-08-01
Budget End
2013-05-31
Support Year
10
Fiscal Year
2012
Total Cost
$522,145
Indirect Cost
$20,776
Name
Rutgers University
Department
Biology
Type
Schools of Arts and Sciences
DUNS #
001912864
City
New Brunswick
State
NJ
Country
United States
Zip Code
08901
Direk, Nese; Williams, Stephanie; Smith, Jennifer A et al. (2017) An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biol Psychiatry 82:322-329
Abdulkadir, Mohamed; Londono, Douglas; Gordon, Derek et al. (2017) Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach. Eur Arch Psychiatry Clin Neurosci :
Bruni, Matthew; Flax, Judy F; Buyske, Steven et al. (2017) Behavioral and Molecular Genetics of Reading-Related AM and FM Detection Thresholds. Behav Genet 47:193-201
Daneshjou, Roxana; Wang, Yanran; Bromberg, Yana et al. (2017) Working toward precision medicine: Predicting phenotypes from exomes in the Critical Assessment of Genome Interpretation (CAGI) challenges. Hum Mutat 38:1182-1192
Treur, Jorien L; Taylor, Amy E; Ware, Jennifer J et al. (2017) Smoking and caffeine consumption: a genetic analysis of their association. Addict Biol 22:1090-1102
Willsey, A Jeremy; Fernandez, Thomas V; Yu, Dongmei et al. (2017) De Novo Coding Variants Are Strongly Associated with Tourette Disorder. Neuron 94:486-499.e9
de Vries, Paul S; Sabater-Lleal, Maria; Chasman, Daniel I et al. (2017) Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study. PLoS One 12:e0167742
Justice, Anne E (see original citation for additional authors) (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 8:14977
Lin, Bochao D; Willemsen, Gonneke; Fedko, Iryna O et al. (2017) Heritability and GWAS Studies for Monocyte-Lymphocyte Ratio. Twin Res Hum Genet 20:97-107
Sun, N; Nasello, C; Deng, L et al. (2017) The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Mol Psychiatry :

Showing the most recent 10 out of 94 publications