Human immunodeficiency virus type-1 (HIV) remains a near-inexorable cause of neurological and behavioral disease (NeuroAIDS) despite the prolonged survival of many HIV-infected (HIV+) individuals associated with use of highly active antiretroviral therapy (HAART). The failure of current HAART regimens to eliminate HIV from the CNS has led to the development of a protected viral reservoir, new forms of HIV associated neurocognitive disorder (HAND), and increasing numbers of age-related neurological disorders in older HIV+ persons. In order to address these evolving issues, investigators require well-characterized human CNS tissues and fluids from well-characterized cohorts. Thus, the human tissues, fluids, and data provided by the National Neurological AIDS Bank (NNAB) and National NeuroAIDS Tissue Consortium (NNTC), remain essential for investigators to perform studies that will benefit HIV+ patients. To date, the NNAB has successfully recruited 719 participants of diverse racial, ethnic, linguistic, and educational backgrounds and both genders. We follow a living cohort of 184 participants, and we have performed 228 autopsies, of which 86% of descendants had pre-mortem study data. We have supplied 216 requests for tissues and data, and we have generated numerous independently funded research projects at UCLA that enhance our resources and further the science of NeuroAIDS. We actively collaborate with the other NNTC clinical sites and the NNTC Data Coordinating Committee (DCC) to maintain an up-to-date central database and specimen inventory and to fulfill requests for tissues, fluids, and data. Since the advent of the NNTC initiative, our participants have lived longer than was anticipated. This has engendered new problems and has forced us to be scientifically nimble and to rapidly adjust to the changing face of the HIV pandemic. The NNAB, adapting in turn, has successful research projects and collaborations that interact with the Bank and advance the very field of NeuroAIDS. We look forward to continuing our work with our colleagues at the other clinical sites, the DCC, and the NIH, on this important and for many, life- changing project.

Public Health Relevance

To develop treatments for NeuroAIDS, researchers require a continuous, reliable source of well- characterized human specimens and data. The National Neurological AIDS Bank (NNAB) is in a unique position to meet the. needs of NeuroAIDS researchers. Over the past 5 years we have been among the top contributors of well-characterized human tissues, fluids and data to the National NeuroAIDS Tissue Consortium (NNTC) and will continue this trend in the future.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24MH100929-02
Application #
8660709
Study Section
Special Emphasis Panel (ZMH1-ERB-C (04))
Program Officer
Rausch, Dianne M
Project Start
2013-05-10
Project End
2018-04-30
Budget Start
2014-08-28
Budget End
2015-04-30
Support Year
2
Fiscal Year
2014
Total Cost
$1,168,985
Indirect Cost
$381,662
Name
University of California Los Angeles
Department
Neurology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Lamers, S L; Fogel, G B; Liu, E S et al. (2017) Predicted coreceptor usage at end-stage HIV disease in tissues derived from subjects on antiretroviral therapy with an undetectable plasma viral load. Infect Genet Evol 51:194-197
Dampier, Will; Antell, Gregory C; Aiamkitsumrit, Benjamas et al. (2017) Specific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status. J Neurovirol 23:113-124
Vitomirov, Andrej; Ramirez-Gaona, Miguel; Mehta, Sanjay R et al. (2017) Random shearing as an alternative to digestion for mitochondrial DNA processing in droplet digital PCR. Mitochondrion 32:16-18
Gupta, Manish K; Kaminski, Rafal; Mullen, Brian et al. (2017) HIV-1 Nef-induced cardiotoxicity through dysregulation of autophagy. Sci Rep 7:8572
Bryant, Alex K; Moore, David J; Burdo, Tricia H et al. (2017) Plasma soluble CD163 is associated with postmortem brain pathology in human immunodeficiency virus infection. AIDS 31:973-979
Solomon, Isaac H; De Girolami, Umberto; Chettimada, Sukrutha et al. (2017) Brain and liver pathology, amyloid deposition, and interferon responses among older HIV-positive patients in the late HAART era. BMC Infect Dis 17:151
Kuhn, Taylor; Sayegh, Philip; Jones, Jacob D et al. (2017) Improvements in brain and behavior following eradication of hepatitis C. J Neurovirol 23:593-602
Castellano, Paul; Prevedel, Lisa; Eugenin, Eliseo A (2017) HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim. Sci Rep 7:12866
Lamers, Susanna L; Fogel, Gary B; Liu, Enoch S et al. (2017) Brain-specific HIV Nef identified in multiple patients with neurological disease. J Neurovirol :
Di Giorgio, Laura; Moses, Mark W; Fullman, Nancy et al. (2016) The potential to expand antiretroviral therapy by improving health facility efficiency: evidence from Kenya, Uganda, and Zambia. BMC Med 14:108

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