The Icahn School of Medicine at Mount Sinai will leverage our research expertise in children's environmental health and the Frank Lautenberg Laboratory for Environmental Health Sciences to form a new Children's Health Exposure Analysis Resource (CHEAR) Laboratory Network Hub. We will measure environmental exposures, both targeted and untargeted, across pregnancy and childhood to help NIH-funded researchers determine how the environment affects child health, development and risk of disease across the life span. Our team will develop new methodologies to objectively reconstruct past chemical exposures, allowing researchers to study susceptibility windows as they relate to child health. Four laboratory resources/cores will be established to achieve these goals; 1) a targeted analysis resource that will analyze common environmental exposure biomarkers (metals, pesticides, flame retardants, endocrine disrupting chemicals, tobacco metabolites, vitamins, nutritional status, minerals, and other organic compounds) using state-of-the-art analytical methodologies; 2) an untargeted analysis resource using advanced technologies such as time-of- flight mass spectrometry to discover the chemicals, metabolites and other biomarkers that are associated with child health and disease; 3) a biological response indicators resource that will link environmental exposures to changes in immune function, epigenomic marks, gene expression, noncoding RNA and other response biomarkers; and 4) we will establish a developmental core that will create novel methods to measure current and past chemical exposures in new biological matrices (e.g. teeth, placenta), develop new assays to study emerging toxicants, and develop new methods to assess the body's response to exposure. An Administrative Core will be established to coordinate planning and communication externally with the CHEAR Coordinating Center, the CHEAR Data Center and the other CHEAR Network Laboratory Hubs. Internally, the Administration Core will integrate work among our Resources/Cores to streamline and prioritize job orders, assess assay needs, promote and disseminate new assays as they are developed, harmonize protocols and QA/QC procedures and coordinate day to day operations. This laboratory Hub will advise applicants on sample requirements, sample quality, results interpretation, sample collection, storage protocols and sample shipping specifications. Both analysis and interpretation of Lab Hub-generated data will be supported in cooperation with the Data Center; and if necessary, we will outreach to outside laboratories with analytic capabilities/expertise that do not reside in our Lab Hub. In conclusion, this proposal links highly experienced environmental health scientists with pediatricians, toxicologists, stress researchers, chemists, exposure scientists, epidemiologists, computer scientists, immunologists, and epigeneticists to build the infrastructure and capacity to objectively measure child environments.

Public Health Relevance

The Mount Sinai Children's Health Exposure Analysis Resource (CHEAR) Laboratory Network Hub will advance public health in the United States by supporting state-of-the-art exposure science and biological response methods designed to discover the environmental causes of disease and disability in children.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Resource-Related Research Multi-Component Projects and Centers Cooperative Agreements (U2C)
Project #
1U2CES026561-01
Application #
9062192
Study Section
Special Emphasis Panel (ZES1-LWJ-J (UC))
Program Officer
Balshaw, David M
Project Start
2015-09-30
Project End
2019-08-31
Budget Start
2015-09-30
Budget End
2019-08-31
Support Year
1
Fiscal Year
2015
Total Cost
$10,400,000
Indirect Cost
$4,022,243
Name
Icahn School of Medicine at Mount Sinai
Department
Pediatrics
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Wright, Robert O; Teitelbaum, Susan; Thompson, Claudia et al. (2018) The child health exposure analysis resource as a vehicle to measure environment in the environmental influences on child health outcomes program. Curr Opin Pediatr 30:285-291
Sanders, Alison P; Saland, Jeffrey M; Wright, Robert O et al. (2018) Perinatal and childhood exposure to environmental chemicals and blood pressure in children: a review of literature 2007-2017. Pediatr Res 84:165-180
Curtin, Paul; Austin, Christine; Curtin, Austen et al. (2018) Dynamical features in fetal and postnatal zinc-copper metabolic cycles predict the emergence of autism spectrum disorder. Sci Adv 4:eaat1293
Smith, Tanya M; Austin, Christine; Hinde, Katie et al. (2017) Cyclical nursing patterns in wild orangutans. Sci Adv 3:e1601517
Wright, Robert O (2017) Environment, susceptibility windows, development, and child health. Curr Opin Pediatr 29:211-217
Andra, Syam S; Austin, Christine; Patel, Dhavalkumar et al. (2017) Trends in the application of high-resolution mass spectrometry for human biomonitoring: An analytical primer to studying the environmental chemical space of the human exposome. Environ Int 100:32-61
Wolff, Mary S; Buckley, Jessie P; Engel, Stephanie M et al. (2017) Emerging exposures of developmental toxicants. Curr Opin Pediatr 29:218-224
Evrard, Solene M; Lecce, Laura; Michelis, Katherine C et al. (2016) Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability. Nat Commun 7:11853
Kappil, Maya; Wright, Robert O; Sanders, Alison P (2016) Developmental Origins of Common Disease: Epigenetic Contributions to Obesity. Annu Rev Genomics Hum Genet 17:177-92
Andra, Syam S; Austin, Christine; Yang, Juan et al. (2016) Recent advances in simultaneous analysis of bisphenol A and its conjugates in human matrices: Exposure biomarker perspectives. Sci Total Environ 572:770-781

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