This proposal for a TB and TB/HIV Training Program is submitted under Phase II """"""""International, Clinical, Operational and Health Services Research Training Awards for AIDS and Tuberculosis"""""""" (Comprehensive ICOHRTA AIDS/TB). The purpose of this application is to create a training program that will allow investigators from Brazil to obtain research training experiences in operational and health services investigation, including epidemiology, surveillance, clinical trials, diagnostics, health economics, systems management, research ethics and other pertinent disciplines that will strenthen the overall tuberculosis research capacity in Brazil. Needs assessments have identified substantial shortcomings in research capacity in TB and TB/HIV in Brazil, and this application specifically targets a number of areas where improved capabilities could result in a strengthening of health services and improvements in human health. The ICOHRTA training program will draw upon the considerable strengths of the Johns Hopkins University and the Federal University of Rio de Janeiro, and build upon a 15-year partnership in carrying out TB and HIV research and training. The program includes partnerships with the Weill Medical College of Cornell University and the University of California, Berkeley, both of which have strong track records in supporting research training in Brazil and which offer unique training opportunities that strengthen the program. In Brazil, partner institutions include the Federal University of Espirito Santo, the Adolpho Lutz Institute and the ? ? Municipal Health Department of Rio de Janeiro. The program will provide training and establish long-term collaborations with young investigators from Brazil, a country with high incidence of tuberculosis and inadequate tuberculosis control programs. A four-tiered training program has been designed to provide basic research skills to a large number of investigators and more intensive experiences for a smaller number of more select candidates with the potential to become leaders in TB and TB/HIV research in Brazil. Research training will be greatly augmented by the broad array of TB and TB/HIV research projects underway in Rio de Janeiro, all of which aim to reduce the burden of these two diseases. The result of this initiative will be a new cadre of clinically- and health services-oriented researchers who can make substantial contributions to the control of tuberculosis both in Brazil and globally in the next decade. ? ?

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
International Research Training Cooperative Agreements (U2R)
Project #
5U2RTW006885-04
Application #
7469561
Study Section
Special Emphasis Panel (ZRG1-ICP-2 (52))
Program Officer
Mcdermott, Jeanne
Project Start
2005-09-23
Project End
2010-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
4
Fiscal Year
2008
Total Cost
$200,925
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Snyder, Robert E; Marlow, Mariel A; Phuphanich, Melissa E et al. (2016) Risk factors for differential outcome following directly observed treatment (DOT) of slum and non-slum tuberculosis patients: a retrospective cohort study. BMC Infect Dis 16:494
Laux da Costa, Lucas; Delcroix, Melaine; Dalla Costa, Elis R et al. (2015) A real-time PCR signature to discriminate between tuberculosis and other pulmonary diseases. Tuberculosis (Edinb) 95:421-5
Queiroz, Adriano; Medina-Cleghorn, Daniel; Marjanovic, Olivera et al. (2015) Comparative metabolic profiling of mce1 operon mutant vs wild-type Mycobacterium tuberculosis strains. Pathog Dis 73:ftv066
Marlow, Mariel A; Maciel, Ethel Leonor Noia; Sales, Carolina Maia Martins et al. (2015) Tuberculosis DALY-Gap: Spatial and Quantitative Comparison of Disease Burden Across Urban Slum and Non-slum Census Tracts. J Urban Health 92:622-34
Rocha, Paulo Novis; Macedo, Michael Nascimento; Kobayashi, Carla Dinamérica et al. (2015) Role of urine neutrophil gelatinase-associated lipocalin in the early diagnosis of amphotericin B-induced acute kidney injury. Antimicrob Agents Chemother 59:6913-21
Rocha, Paulo Novis; Kobayashi, Carla Dinamérica; de Carvalho Almeida, Luna et al. (2015) Incidence, Predictors, and Impact on Hospital Mortality of Amphotericin B Nephrotoxicity Defined Using Newer Acute Kidney Injury Diagnostic Criteria. Antimicrob Agents Chemother 59:4759-69
Azadi, M; Bishai, D M; Dowdy, D W et al. (2014) Cost-effectiveness of tuberculosis screening and isoniazid treatment in the TB/HIV in Rio (THRio) Study. Int J Tuberc Lung Dis 18:1443-8
Saraceni, Valeria; Cohn, Silvia; Cavalcante, Solange C et al. (2014) Prevalent tuberculosis at HIV diagnosis in Rio de Janeiro, Brazil: the TB/HIV in Rio (THRio) Cohort. J Acquir Immune Defic Syndr 67:98-101
Silva Júnior, José Laerte R; Conde, Marcus Barreto; de Sousa Corrêa, Krislainy et al. (2014) COPD Assessment Test (CAT) score as a predictor of major depression among subjects with chronic obstructive pulmonary disease and mild hypoxemia: a case-control study. BMC Pulm Med 14:186
Vinhas, Solange Alves; Palaci, Moises; Marques, Hebert Silva et al. (2013) Mycobacterium tuberculosis DNA fingerprint clusters and its relationship with RD(Rio) genotype in Brazil. Tuberculosis (Edinb) 93:207-12

Showing the most recent 10 out of 50 publications