Tuberculosis (TB) is still a major public health challenge in Brazil. Though Brazil has moved down the list of WHO'S 22 high burden countries, it still remains 18th. This burden makes Brazil particularly suitable for TB/HIV research as one of the few low- and middle-income countries with free and universal access to both anti-TB and HAART drugs provided by the public health system. The ICOHRTA AIDS/TB in Brazil succeeded in training a cadre of investigators working in the public health system and academic institutions. This renewal application in response to PAR-08-155 intends to continue this mission of training highly motivated investigators with capacity to sustain research with impact in TB and AIDS control. This Phase I! ICOHRTA AIDS/TB grant is integrated with other awards received by the Academic Program of TB, Federal University of Rio de Janeiro (FURJ) and the Center for TB Research, Johns Hopkins University including ICIDR (NIAID), CREATE (Melinda and Bill Gates Foundation), TREAT-TB (USAID), as well as other Important Brazilian awards, such as the National Institute of Science and Technology in TB, awarded by the CNPq. Since September 2005, 1,332 Brazilian trainees have participated in ICOHRTA activities;45 have received or will receive M.Sc. or PhD degrees, or post-doctoral training by Brazilian Universities;and over 80 publications have appeared in peer-reviewed journals. Former trainees are now faculty members in this renewal application and others work in leadership positions in the public health system. ICOHRTA faculty members are also involved in the fight to control TB in Brazil, working closely with the Brazilian TB Control Program, the Brazilian Society of Thoracic Diseases and TB, the TB Research Network (REDE-TB), and with organizations of the civil societies at the Stop TB Partnership and the Country Coordination Mechanism of the Global Fund. This renewal proposal intends to expand training activities to other high burden areas, such as Fortaleza and Salvador in the North-East region, and Porto Alegre in the South region. Other centers in the original areas of Rio de Janeiro, S^o Paulo, and Vitoria will also participate. The main goal of the renewal application is to continue its contribution to TB control in Brazil.

Agency
National Institute of Health (NIH)
Type
International Research Training Cooperative Agreements (U2R)
Project #
5U2RTW006885-10
Application #
8689200
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Mcdermott, Jeanne
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Saraceni, Valeria; Cohn, Silvia; Cavalcante, Solange C et al. (2014) Prevalent tuberculosis at HIV diagnosis in Rio de Janeiro, Brazil: the TB/HIV in Rio (THRio) Cohort. J Acquir Immune Defic Syndr 67:98-101
Trajman, A; Steffen, R E; Menzies, D (2013) Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection: An Overview of the Evidence. Pulm Med 2013:601737
Steffen, Ricardo Ewbank; Caetano, Rosângela; Pinto, Márcia et al. (2013) Cost-effectiveness of Quantiferon®-TB Gold-in-Tube versus tuberculin skin testing for contact screening and treatment of latent tuberculosis infection in Brazil. PLoS One 8:e59546
Soares, E C C; Vollmer, W M; Cavalcante, S C et al. (2013) Tuberculosis control in a socially vulnerable area: a community intervention beyond DOT in a Brazilian favela. Int J Tuberc Lung Dis 17:1581-6
Takenami, Iukary; Loureiro, Camila; Machado Jr, Almerio et al. (2013) Blood Cells and Interferon-Gamma Levels Correlation in Latent Tuberculosis Infection. ISRN Pulmonol 2013:
Dowdy, D W; Israel, G; Vellozo, V et al. (2013) Quality of life among people treated for tuberculosis and human immunodeficiency virus in Rio de Janeiro, Brazil. Int J Tuberc Lung Dis 17:345-7
Reis-Santos, Barbara; Locatelli, Rodrigo; Horta, Bernardo L et al. (2013) Socio-demographic and clinical differences in subjects with tuberculosis with and without diabetes mellitus in Brazil--a multivariate analysis. PLoS One 8:e62604
Vinhas, Solange Alves; Palaci, Moises; Marques, Hebert Silva et al. (2013) Mycobacterium tuberculosis DNA fingerprint clusters and its relationship with RD(Rio) genotype in Brazil. Tuberculosis (Edinb) 93:207-12
Rocha, Adalgiza; Elias, Atina R; Sobral, Luciana F et al. (2011) Genotyping did not evidence any contribution of Mycobacterium bovis to human tuberculosis in Brazil. Tuberculosis (Edinb) 91:14-21
Vasconcellos, Sidra E Goncalves; Huard, Richard C; Niemann, Stefan et al. (2010) Distinct genotypic profiles of the two major clades of Mycobacterium africanum. BMC Infect Dis 10:80

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