Abstract

(?Resource Informatics and Production Core? ? PRELIMINARY RESULTS) As noted in the OVERALL section, we are using SECTION C to present our PRELIMINARY RESULTS. In this section, we describe our experimental pipeline, the current status of the data production, and the analysis of the first set of networks derived from AP-MS analysis of 2594 bait proteins.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Biotechnology Resource Cooperative Agreements (U41)
Project #
2U41HG006673-04
Application #
8933271
Study Section
Ethical, Legal, Social Implications Review Committee (GNOM)
Project Start
Project End
Budget Start
2015-09-01
Budget End
2016-06-30
Support Year
4
Fiscal Year
2015
Total Cost
$873,863
Indirect Cost
$255,802

  Institution

Name
Harvard Medical School
Department
Type
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Schweppe, Devin K; Huttlin, Edward L; Harper, J Wade et al. (2018) BioPlex Display: An Interactive Suite for Large-Scale AP-MS Protein-Protein Interaction Data. J Proteome Res 17:722-726
Gu, Xin; Orozco, Jose M; Saxton, Robert A et al. (2017) SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway. Science 358:813-818
Paek, Jaeho; Kalocsay, Marian; Staus, Dean P et al. (2017) Multidimensional Tracking of GPCR Signaling via Peroxidase-Catalyzed Proximity Labeling. Cell 169:338-349.e11
Anikster, Yair; Haack, Tobias B; Vilboux, Thierry et al. (2017) Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability. Am J Hum Genet 100:257-266
Huttlin, Edward L; Bruckner, Raphael J; Paulo, Joao A et al. (2017) Architecture of the human interactome defines protein communities and disease networks. Nature 545:505-509
Chick, Joel M; Munger, Steven C; Simecek, Petr et al. (2016) Defining the consequences of genetic variation on a proteome-wide scale. Nature 534:500-5
Yang, Wen; Nagasawa, Koji; Münch, Christian et al. (2016) Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell 167:985-1000.e21
Chantranupong, Lynne; Scaria, Sonia M; Saxton, Robert A et al. (2016) The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. Cell 165:153-164
Huttlin, Edward L; Ting, Lily; Bruckner, Raphael J et al. (2015) The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell 162:425-440
McAlister, Graeme C; Nusinow, David P; Jedrychowski, Mark P et al. (2014) MultiNotch MS3 enables accurate, sensitive, and multiplexed detection of differential expression across cancer cell line proteomes. Anal Chem 86:7150-8

Showing the most recent 10 out of 11 publications