MANAGEMENT, DISSEMINATION AND TRAINING - PROJECT SUMMARY The management, dissemination and training planned for the next four years of GENCODE will largely continue the practices found to be successful in the current project. The major difference for this proposal is the transition of the project to EMBL-EBI. The date of final transition for the WTSI HAVANA team is set for 1 April 2017, coincident with the start of the proposed funding from this application, and will follow an orderly process informed by previous resource transitions from WTSI to EMBL-EBI. As the technical transition proceeds, we will move computational and software infrastructure from WTSI to EMBL-EBI through 2016 and early 2017, and provide HAVANA staff with guest logins to for testing before transition. The staff and physical transition will occur in 2017. All HAVANA staff moving to EMBL-EBI will be offered EMBL contracts with a start date of 1 April 2017. In terms of project management, the Scientific Advisory Board (SAB) will continue to provide advice on all aspects of the project, including progress, priorities, new technologies, operational processes of the consortium, and will also serve as representatives of the user community. The SAB will meet annually. A Research Support Officer will be deployed at 0.5 FTE on the project to organize the annual SAB meetings, and also to ensure regular meetings and teleconferences between the partners, as well as regular updates and reports. In terms of access, the major aims for GENCODE are regular releases of annotation; maintenance and extension of the existing GENCODE portal website (www.gencodegenes.org) providing information to the research and clinical community working on human and mouse genetics and genomics; and the design and implementation of new web interfaces. Annotation will be released through the Ensembl and UCSC browsers, as well as via FTP and HTTP, and Track Hubs. The GENCODE portal, used for dedicated data download and specific project news, will be expanded to provide in-depth documentation and details of the processes used within the GENCODE consortium. To further aid data access and discovery via the Ensembl website, new views of visually highlighting the differences and similarities in annotation for different strains of mice will be developed. The training plans for the next phase of GENCODE include extensive workshops, on the use of GENCODE annotation, how to use GENCODE tools, and how to submit annotation to the public genomic archives. Support for users will also be provided remotely by an email Helpdesk, where queries will be tracked by Request Tracker.

Agency
National Institute of Health (NIH)
Institute
National Human Genome Research Institute (NHGRI)
Type
Biotechnology Resource Cooperative Agreements (U41)
Project #
2U41HG007234-05
Application #
9277659
Study Section
Special Emphasis Panel (ZHG1)
Project Start
Project End
Budget Start
2017-05-15
Budget End
2018-04-30
Support Year
5
Fiscal Year
2017
Total Cost
Indirect Cost
Name
European Molecular Biology Laboratory
Department
Type
DUNS #
321691735
City
Heidelberg
State
Country
Germany
Zip Code
69117
Garrison, Erik; Sirén, Jouni; Novak, Adam M et al. (2018) Variation graph toolkit improves read mapping by representing genetic variation in the reference. Nat Biotechnol 36:875-879
Schlaffner, Christoph N; Pirklbauer, Georg J; Bender, Andreas et al. (2018) A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes. J Vis Exp :
Garg, Shilpa; Rautiainen, Mikko; Novak, Adam M et al. (2018) A graph-based approach to diploid genome assembly. Bioinformatics 34:i105-i114
Lagarde, Julien; Johnson, Rory (2018) Capturing a Long Look at Our Genetic Library. Cell Syst 6:153-155
Lilue, Jingtao; Doran, Anthony G; Fiddes, Ian T et al. (2018) Sixteen diverse laboratory mouse reference genomes define strain-specific haplotypes and novel functional loci. Nat Genet 50:1574-1583
Schoeler, Natasha E; Leu, Costin; Balestrini, Simona et al. (2018) Genome-wide association study: Exploring the genetic basis for responsiveness to ketogenic dietary therapies for drug-resistant epilepsy. Epilepsia 59:1557-1566
Pujar, Shashikant; O'Leary, Nuala A; Farrell, Catherine M et al. (2018) Consensus coding sequence (CCDS) database: a standardized set of human and mouse protein-coding regions supported by expert curation. Nucleic Acids Res 46:D221-D228
Newman, Victoria; Moore, Benjamin; Sparrow, Helen et al. (2018) The Ensembl Genome Browser: Strategies for Accessing Eukaryotic Genome Data. Methods Mol Biol 1757:115-139
Wang, Junling; Pejaver, Vikas Rao; Dann, Geoffrey P et al. (2018) Target site specificity and in vivo complexity of the mammalian arginylome. Sci Rep 8:16177
Zerbino, Daniel R; Achuthan, Premanand; Akanni, Wasiu et al. (2018) Ensembl 2018. Nucleic Acids Res 46:D754-D761

Showing the most recent 10 out of 88 publications