? MANAGEMENT, DISSEMINATION AND TRAINING The RegulomeDB project is managed by an experienced team of scientist that have been colleagues for over 5 years. We will utilize management practices to promote an efficient team, allowing enhancement and growth of technology and community engagement. We will maintain the highest quality training for out staff to maintain standards for quality and accessibility. We will provide effective tutorials via text or video for use of RegulomeDB.
TO PUBLIC HEALTH, PROJECT NARRATIVE The regulation of gene expression controls the determination of cell types, and aberrant gene expression can cause diseases such as cancer. RegulomeDB will enable researchers, clinicians, and sophisticated computer programs to relate DNA variants that lie in previously poorly understood regions of the human genome to possible functions thereby helping us understand the genetic basis of human variation and disease.
|Nielsen, Jonas B; Fritsche, Lars G; Zhou, Wei et al. (2018) Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development. Am J Hum Genet 102:103-115|
|Nishizaki, Sierra S; Boyle, Alan P (2017) Mining the Unknown: Assigning Function to Noncoding Single Nucleotide Polymorphisms. Trends Genet 33:34-45|
|Yang, Bo; Zhou, Wei; Jiao, Jiao et al. (2017) Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve. Nat Commun 8:15481|