A safe and effective vaccine remains the best hope of controlling the human immunodeficiency virus (HIV) pandemic. Because of the similarity of the immune system of the Indian-origin rhesus macaques and humans, vaccine development is heavily dependent on the SIV and SHIV macaque models. The need for Indian rhesus macaques for AIDS-related research continues to exceed availability. Efficient domestic breeding programs managed to produce well characterized animals that enhance their use in biomedical research and offer the best long term solution for the current shortage of Indian-origin rhesus macaques for AIDS vaccine and pathogenesis studies and to insure future availability. The purposes of this proposal are to continue to support and characterize the specific pathogen-free Indian rhesus AIDS Research Colony resource that was established in the past ten-year grant period.

Public Health Relevance

The objective of this application is to continue to maintain and genetically characterize the colony to maximize the usefulness in biomedical research. The colony was initiated in 2001 and now provides approximately 200 macaques for U.S. Public Health Service supported AIDS research.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
5U42OD010426-12
Application #
8601761
Study Section
Special Emphasis Panel (ZTR1-CM-6 (01))
Program Officer
Contreras, Miguel A
Project Start
2013-01-01
Project End
2016-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
12
Fiscal Year
2014
Total Cost
$322,133
Indirect Cost
$138,057
Name
Oregon Health and Science University
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
Urbanski, Henryk F (2017) Effect of androgen supplementation on 24-hour activity-rest patterns of aged male rhesus macaques. Neurobiol Aging 54:100-102
Eghlidi, Dominique H; Garyfallou, Vasilios T; Kohama, Steven G et al. (2017) Age-associated gene expression changes in the arcuate nucleus of male rhesus macaques. J Mol Endocrinol 59:141-149
Rais, Maham; Wilson, Randall M; Urbanski, Henryk F et al. (2017) Androgen supplementation improves some but not all aspects of immune senescence in aged male macaques. Geroscience :
DeGottardi, Maren Q; Okoye, Afam A; Vaidya, Mukta et al. (2016) Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol 197:1183-98
McBurney, Sean P; Sunshine, Justine E; Gabriel, Sarah et al. (2016) Evaluation of protection induced by a dengue virus serotype 2 envelope domain III protein scaffold/DNA vaccine in non-human primates. Vaccine 34:3500-7
Yee, JoAnn L; Vanderford, Thomas H; Didier, Elizabeth S et al. (2016) Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management. J Med Primatol 45:55-78
Meyer, C; Walker, J; Dewane, J et al. (2015) Impact of irradiation and immunosuppressive agents on immune system homeostasis in rhesus macaques. Clin Exp Immunol 181:491-510
Yang, Otto O; Ali, Ayub; Kasahara, Noriyuki et al. (2015) Short conserved sequences of HIV-1 are highly immunogenic and shift immunodominance. J Virol 89:1195-204
Meyer, Christine; Engelmann, Flora; Arnold, Nicole et al. (2015) Abortive intrabronchial infection of rhesus macaques with varicella-zoster virus provides partial protection against simian varicella virus challenge. J Virol 89:1781-93
Okoye, Afam A; Rohankhedkar, Mukta; Konfe, Audrie L et al. (2015) Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques. J Immunol 195:4292-305

Showing the most recent 10 out of 48 publications