Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community. Since the MMRRC Network began as a fledging repository in 1999/2000, it has evolved into a major resource for the biomedical community with capabilities and a combined inventory of mouse lines and embryonic stem (ES) cells that exceeds the capacity of other mouse repositories worldwide. The overall goal of this proposal is to continue and expand these functions and capabilities of the Mutant Mouse Regional Resource Center (MMRRC) at the University of Missouri to provide biomedical investigators with the mouse models and related reagents they require for their research.

Public Health Relevance

Genetically-engineered mice (transgenics, knockout and knock-ins) have become invaluable to almost all fields of medicine. Because of the importance of GEM to understanding human development and diseases and to creating improved drugs and therapeutics, tens of thousands of GEM have been created over the last decade. The MMRRC provides a unique repository service to the biomedical community for importing, storing and distributing a vast number of GEM as a resource for the biomedical community.

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
Project #
3U42OD010918-15S2
Application #
8917439
Study Section
Special Emphasis Panel (ZRR1-CM-9 (01))
Program Officer
Mirochnitchenko, Oleg
Project Start
2000-05-01
Project End
2015-01-31
Budget Start
2014-09-06
Budget End
2015-01-31
Support Year
15
Fiscal Year
2014
Total Cost
$10,000
Indirect Cost
$3,330
Name
University of Missouri-Columbia
Department
Veterinary Sciences
Type
Schools of Veterinary Medicine
DUNS #
153890272
City
Columbia
State
MO
Country
United States
Zip Code
65211
Ericsson, Aaron C; Personett, Alexa R; Turner, Giedre et al. (2017) Variable Colonization after Reciprocal Fecal Microbiota Transfer between Mice with Low and High Richness Microbiota. Front Microbiol 8:196
Franklin, Craig L; Ericsson, Aaron C (2017) Microbiota and reproducibility of rodent models. Lab Anim (NY) 46:114-122
Ericsson, Aaron C; Montonye, Daniel R; Smith, Cierra R et al. (2017) Modeling a Superorganism - Considerations Regarding the Use of ""Dirty"" Mice in Biomedical Research?. Yale J Biol Med 90:361-371
Hart, Marcia L; Ericsson, Aaron C; Franklin, Craig L (2017) Differing Complex Microbiota Alter Disease Severity of the IL-10-/- Mouse Model of Inflammatory Bowel Disease. Front Microbiol 8:792
Khairallah, Marie-Therese; Astroski, Jacob; Custer, Sarah K et al. (2017) SMN deficiency negatively impacts red pulp macrophages and spleen development in mouse models of spinal muscular atrophy. Hum Mol Genet 26:932-941
Toth, Linda A; Trammell, Rita A; Liberati, Teresa et al. (2017) Influence of Chronic Exposure to Simulated Shift Work on Disease and Longevity in Disease-Prone Inbred Mice. Comp Med 67:116-126
Brodeur, Amanda C; Roberts-Pilgrim, Anna M; Thompson, Kimberlee L et al. (2017) Transforming growth factor-?1/Smad3-independent epithelial-mesenchymal transition in type I collagen glomerulopathy. Int J Nephrol Renovasc Dis 10:251-259
Alvarado, Cynthia G; Franklin, Craig L; Dixon, Lonny W (2016) Retrospective Evaluation of Nail Trimming as a Conservative Treatment for Ulcerative Dermatitis in Laboratory Mice. J Am Assoc Lab Anim Sci 55:462-6
Ray, Avijit; Basu, Sreemanti; Gharaibeh, Raad Z et al. (2015) Gut Microbial Dysbiosis Due to Helicobacter Drives an Increase in Marginal Zone B Cells in the Absence of IL-10 Signaling in Macrophages. J Immunol 195:3071-85
Ericsson, Aaron C; Franklin, Craig L (2015) Manipulating the Gut Microbiota: Methods and Challenges. ILAR J 56:205-17

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