This proposal seeks renewal of support for the infrastructure, personnel, and resources of the Mutant Mouse Resource and Research Center (MMRRC) at the University of California (UC) Davis (MMRRC-UCD). Since its inception 15 years ago, the MMRRC-UCD has been one of the primary mutant mouse archive and distribution repositories in the world. We are the largest of the 4 Centers in the MMRRC National Program, with an archive of over 30,392 mutant alleles representing ~93% of all live colonies, germplasm, and/or embryonic stem (ES) cells in the MMRRC system. The MMRRC-UCD has fulfilled nearly 4,754 orders from 3,214 investigators at 1,956 institutions in 23 countries. We have also been a leader in innovation and resource development for the system, introducing new products (e.g., targeted and gene trap ES cells) and initiating new services (e.g., blastocyst injection, ICSI, speed congenics) that have added scientific value to mouse models and enhanced utilization by the scientific research community of the MMRRC National Program. The MMRRC-UCD has leveraged its infrastructure and expertise to extend its service role by contracting with categorical NIH institutes (e.g., NINDS GENSAT project), biotechnology companies (Genentech and Lexicon), and several organizations (e.g., The Sanger Institute, Rockefeller University) to archive, distribute, custom breed, genotype, and phenotype 1000's of ES cell mutants and more than 1,500 BAC-transgenic, CRE, ENU-induced, and other mutant mouse collections. In addition, we have worked with the Centers and NIH program staff and developed and implemented advertising and marketing strategies, database management and informatics applications, website and online resources, customer and user services, operating procedures and policies, and shared governance of the national program. Thus, by archiving and delivering products and services effectively and efficiently, the MMRRC-UCD has established itself as a valuable scientific resource for the biomedical research community. Over the next 5 years, we shall focus our efforts on optimizing the quality of our resource, ensuring it relevance to individual users, and seeking maximum performance for the benefit of all whom we serve.

Public Health Relevance

The Mutant Mouse Resource and Research Center (MMRRC) National Consortium serves a primary role in ensuring that valuable mouse models of human disease, development, and behavioral abnormalities created in research laboratories are shared broadly among the biomedical scientific community. As one of 4 regional repositories and distribution centers in the Consortium, the MMRRC-UCD provides expertise, infrastructure, resources and services to preserve mouse strains in perpetuity, protect them from catastrophic loss, avoid genetic and phenotypic drift, and prevent pathogenic contamination and disease. By enabling availability and access of such valuable mouse models to the entire research community, the MMRRC-UCD fosters and promotes the discovery of new diagnostics, treatments, and prevention strategies against human diseases.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Animal (Mammalian and Nonmammalian) Model, and Animal and Biological Materials Resource Cooperative Agreements (U42)
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Special Emphasis Panel (ZRG1)
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Mirochnitchenko, Oleg
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University of California Davis
Schools of Medicine
United States
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Meehan, Terrence F; Conte, Nathalie; West, David B et al. (2017) Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nat Genet 49:1231-1238
Fidler, Trevor P; Middleton, Elizabeth A; Rowley, Jesse W et al. (2017) Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol 37:1628-1639
Jung, Chris J; Zhang, Junli; Trenchard, Elizabeth et al. (2017) Efficient gene targeting in mouse zygotes mediated by CRISPR/Cas9-protein. Transgenic Res 26:263-277
Green, Adrian J; Graham, James L; Gonzalez, Eduardo A et al. (2017) Perinatal triphenyl phosphate exposure accelerates type 2 diabetes onset and increases adipose accumulation in UCD-type 2 diabetes mellitus rats. Reprod Toxicol 68:119-129
Vogel Ciernia, Annie; Pride, Michael C; Durbin-Johnson, Blythe et al. (2017) Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet 26:1839-1854
Moshiri, Ala; Humpal, Devin; Leonard, Brian C et al. (2017) Arap1 Deficiency Causes Photoreceptor Degeneration in Mice. Invest Ophthalmol Vis Sci 58:1709-1718
Fidler, Trevor P; Campbell, Robert A; Funari, Trevor et al. (2017) Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep 20:881-894
Trindade-da-Silva, Carlos Antonio; Bettaieb, Ahmed; Napimoga, Marcelo Henrique et al. (2017) Soluble Epoxide Hydrolase Pharmacological Inhibition Decreases Alveolar Bone Loss by Modulating Host Inflammatory Response, RANK-Related Signaling, Endoplasmic Reticulum Stress, and Apoptosis. J Pharmacol Exp Ther 361:408-416
Lee, Linda L; Aung, Hnin H; Wilson, Dennis W et al. (2017) Triglyceride-rich lipoprotein lipolysis products increase blood-brain barrier transfer coefficient and induce astrocyte lipid droplets and cell stress. Am J Physiol Cell Physiol 312:C500-C516
Roberts, Megan N; Wallace, Marita A; Tomilov, Alexey A et al. (2017) A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab 26:539-546.e5

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