Developmental Projects are short term - one to two years - investments that can generate high yields. GLRCE periodically releases requests for proposals (RFPs) for these projects by posting them on the GLRCE website and by sending RFP invitational e-mails to all GLRCE Executive Board members and to all departmental heads of the Center's member institutions. Developmental projects may involve scientists within the RCE or may extend to appropriate regional scientists outside the Center. Applications are reviewed and rank-ordered by the Executive Board, endorsed by the GLRCE Scientific Advisory Board, and then approved by NIAID RCE Program Management. Criteria for the selection of proposals include, first, criteria related to Scientific merit, and, second, Center-related criteria, where the proposed work has the potential to: expand the scope and range of research of GLRCE;use or enhance existing GLRCE resources; expand the range of investigators and institutions involved in GLRCE;relate to the overall RCE themes;and, leverage resources and complement the Center's strengths. Progress of the Developmental Projects is closely monitored through monthly fiscal reporting, quarterly written progress reports, annual site visits, written annual reports/renewal applications as well as oral or poster presentations at the Center's annual meeting. The Executive Board and Scientific Advisory Board together with the GLRCE Administrative Core's support will terminate funding for developmental projects not demonstrating appropriate progress.
Developmental projects are intended to expand the Center's portfolio of scientific researchers and research programs. In addition to projects with defined expectations, the Center needs to test exciting new ideas whose success is uncertain but that may generate quantum leaps of new information with translational opportunity. It is this type of investment that the Center seeks in Developmental Projects program.
|Sloup, Rudolph E; Konal, Ashley E; Severin, Geoffrey B et al. (2017) Cyclic Di-GMP and VpsR Induce the Expression of Type II Secretion in Vibrio cholerae. J Bacteriol 199:|
|Chen, Grischa Y; McDougal, Courtney E; D'Antonio, Marc A et al. (2017) A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for Listeria monocytogenes Cytosolic Survival. MBio 8:|
|Coulson, Garry B; Johnson, Benjamin K; Zheng, Huiqing et al. (2017) Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics. Cell Chem Biol 24:993-1004.e4|
|Hollands, Andrew; Corriden, Ross; Gysler, Gabriela et al. (2016) Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem 291:13964-73|
|Kuhn, Misty L; Alexander, Evan; Minasov, George et al. (2016) Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis. ACS Infect Dis 2:579-591|
|Duckworth, Benjamin P; Wilson, Daniel J; Aldrich, Courtney C (2016) Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay. Methods Mol Biol 1401:53-61|
|Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng et al. (2016) Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nat Commun 7:10710|
|Agostoni, Marco; Waters, Christopher M; Montgomery, Beronda L (2016) Regulation of biofilm formation and cellular buoyancy through modulating intracellular cyclic di-GMP levels in engineered cyanobacteria. Biotechnol Bioeng 113:311-9|
|Völlger, Lena; Akong-Moore, Kathryn; Cox, Linda et al. (2016) Iron-chelating agent desferrioxamine stimulates formation of neutrophil extracellular traps (NETs) in human blood-derived neutrophils. Biosci Rep 36:|
|Le, J; Dam, Q; Schweizer, M et al. (2016) Effects of vancomycin versus nafcillin in enhancing killing of methicillin-susceptible Staphylococcus aureus causing bacteremia by human cathelicidin LL-37. Eur J Clin Microbiol Infect Dis 35:1441-7|
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