Developmental Projects are short term - one to two years - investments that can generate high yields. GLRCE periodically releases requests for proposals (RFPs) for these projects by posting them on the GLRCE website and by sending RFP invitational e-mails to all GLRCE Executive Board members and to all departmental heads of the Center's member institutions. Developmental projects may involve scientists within the RCE or may extend to appropriate regional scientists outside the Center. Applications are reviewed and rank-ordered by the Executive Board, endorsed by the GLRCE Scientific Advisory Board, and then approved by NIAID RCE Program Management. Criteria for the selection of proposals include, first, criteria related to Scientific merit, and, second, Center-related criteria, where the proposed work has the potential to: expand the scope and range of research of GLRCE;use or enhance existing GLRCE resources; expand the range of investigators and institutions involved in GLRCE;relate to the overall RCE themes;and, leverage resources and complement the Center's strengths. Progress of the Developmental Projects is closely monitored through monthly fiscal reporting, quarterly written progress reports, annual site visits, written annual reports/renewal applications as well as oral or poster presentations at the Center's annual meeting. The Executive Board and Scientific Advisory Board together with the GLRCE Administrative Core's support will terminate funding for developmental projects not demonstrating appropriate progress.

Public Health Relevance

Developmental projects are intended to expand the Center's portfolio of scientific researchers and research programs. In addition to projects with defined expectations, the Center needs to test exciting new ideas whose success is uncertain but that may generate quantum leaps of new information with translational opportunity. It is this type of investment that the Center seeks in Developmental Projects program.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI057153-08
Application #
8233348
Study Section
Special Emphasis Panel (ZAI1)
Project Start
2011-03-01
Project End
2014-02-28
Budget Start
2011-03-01
Budget End
2012-02-29
Support Year
8
Fiscal Year
2011
Total Cost
$626,518
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Hoang, Ky V; Rajaram, Murugesan V S; Curry, Heather Marie et al. (2018) Complement Receptor 3-Mediated Inhibition of Inflammasome Priming by Ras GTPase-Activating Protein During Francisella tularensis Phagocytosis by Human Mononuclear Phagocytes. Front Immunol 9:561
Mitchell, Anthony; Tam, Christina; Elli, Derek et al. (2017) Glutathionylation of Yersinia pestis LcrV and Its Effects on Plague Pathogenesis. MBio 8:
Chen, Grischa Y; McDougal, Courtney E; D'Antonio, Marc A et al. (2017) A Genetic Screen Reveals that Synthesis of 1,4-Dihydroxy-2-Naphthoate (DHNA), but Not Full-Length Menaquinone, Is Required for Listeria monocytogenes Cytosolic Survival. MBio 8:
Sloup, Rudolph E; Konal, Ashley E; Severin, Geoffrey B et al. (2017) Cyclic Di-GMP and VpsR Induce the Expression of Type II Secretion in Vibrio cholerae. J Bacteriol 199:
Kant, Sashi; Asthana, Shailendra; Missiakas, Dominique et al. (2017) A novel STK1-targeted small-molecule as an ""antibiotic resistance breaker"" against multidrug-resistant Staphylococcus aureus. Sci Rep 7:5067
Coulson, Garry B; Johnson, Benjamin K; Zheng, Huiqing et al. (2017) Targeting Mycobacterium tuberculosis Sensitivity to Thiol Stress at Acidic pH Kills the Bacterium and Potentiates Antibiotics. Cell Chem Biol 24:993-1004.e4
Hollands, Andrew; Corriden, Ross; Gysler, Gabriela et al. (2016) Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity. J Biol Chem 291:13964-73
Kuhn, Misty L; Alexander, Evan; Minasov, George et al. (2016) Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis. ACS Infect Dis 2:579-591
Duckworth, Benjamin P; Wilson, Daniel J; Aldrich, Courtney C (2016) Measurement of Nonribosomal Peptide Synthetase Adenylation Domain Activity Using a Continuous Hydroxylamine Release Assay. Methods Mol Biol 1401:53-61
Park, Sung Ryeol; Tripathi, Ashootosh; Wu, Jianfeng et al. (2016) Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway. Nat Commun 7:10710

Showing the most recent 10 out of 516 publications