Our nation's ability to detect, prevent and counter bioterrorism and emerging infectious diseases depends on technologies that are generated through biomedical research on disease-causing microbes and the human immune system's response to them. The National Institute of Allergy and Infectious Diseases (NIAID) established the RCE Network, i.e. the Research Centers of Excellence for Biodefense and Emerging Infectious Diseases, to gain appreciation of the molecular mechanisms whereby microbial pathogens cause human disease. Acquisition of this knowledge enables the development of products designed to prevent, diagnose, and treat diseases caused by agents of bioterrorism or newly emerging pathogens (NIAID Category A-C agents). We present here the Competitive Renewal Application of the Great Lakes (Region V) RCE, abbreviated GLRCE. The GLRCE s a consortium of research institutions in Illinois, Indiana, Michigan, Minnesota, Ohio and Wisconsin. Organized by its Administrative Core at the University of Chicago, GLRCE includes all premier research institutions in this region, which are Argonne National Laboratory, Battelle Memorial Institute, Illinois State University, Indiana University, Loyola University, Mayo Clinic, Medical College of Wisconsin, Michigan State University, Notre Dame University, Northwestern University, Ohio State University, Purdue University, University of Chicago, University of Cincinnati, University of Illinois, University of Michigan, University of Minnesota, and the University of Wisconsin. In addition to research on biodefense products, the GLRCE provides a network of expertise, education and laboratory infrastructure that serves the nation during biodefense and other infectious disease emergencies. The GLRCE proposes an educational program for public health officials as well as training programs for scientific excellence at the post-doctoral and faculty level. Research and training at the GLRCE is governed by a mechanism involving ongoing review of scientific excellence and translational goals, inter-institutional advisory boards and external scientific advisory bodies.

Public Health Relevance

The National Institute of Allergy and Infectious Diseases (NIAID) established the RCE Network, to gain appreciation of the molecular mechanisms whereby microbial pathogens cause human disease. Acquisition of this knowledge enables the development of products designed to prevent, diagnose, and treat diseases caused by agents of bioterrorism or newly emerging pathogens (NIAID Category A-C agents).

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI057153-09
Application #
8233350
Study Section
Special Emphasis Panel (ZAI1-DDS-M (J1))
Program Officer
Schaefer, Michael R
Project Start
2003-09-04
Project End
2014-02-28
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
9
Fiscal Year
2012
Total Cost
$7,527,882
Indirect Cost
$1,821,644
Name
University of Chicago
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Sharma, Preeti; Wang, Ningyan; Kranz, David M (2014) Soluble T cell receptor V? domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens. Toxins (Basel) 6:556-74
Schuld, Nathan J; Vervacke, Jeffrey S; Lorimer, Ellen L et al. (2014) The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. J Biol Chem 289:6862-76
Becker, Russell E N; Berube, Bryan J; Sampedro, Georgia R et al. (2014) Tissue-specific patterning of host innate immune responses by Staphylococcus aureus ?-toxin. J Innate Immun 6:619-31
Pensinger, Daniel A; Aliota, Matthew T; Schaenzer, Adam J et al. (2014) Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to ?-lactam antibiotics. Antimicrob Agents Chemother 58:4486-94
Stach, Christopher S; Herrera, Alfa; Schlievert, Patrick M (2014) Staphylococcal superantigens interact with multiple host receptors to cause serious diseases. Immunol Res 59:177-81
Schiano, Chelsea A; Koo, Jovanka T; Schipma, Matthew J et al. (2014) Genome-wide analysis of small RNAs expressed by Yersinia pestis identifies a regulator of the Yop-Ysc type III secretion system. J Bacteriol 196:1659-70
Merriman, Joseph A; Nemeth, Kimberly A; Schlievert, Patrick M (2014) Novel antimicrobial peptides that inhibit gram positive bacterial exotoxin synthesis. PLoS One 9:e95661
Lifshitz, Ziv; Burstein, David; Schwartz, Kierstyn et al. (2014) Identification of novel Coxiella burnetii Icm/Dot effectors and genetic analysis of their involvement in modulating a mitogen-activated protein kinase pathway. Infect Immun 82:3740-52
Wang, Ya-Ting; Missiakas, Dominique; Schneewind, Olaf (2014) GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. J Bacteriol 196:2969-78
Schneewind, Olaf; Missiakas, Dominique (2014) Genetic manipulation of Staphylococcus aureus. Curr Protoc Microbiol 32:Unit 9C.3.

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