Developmental Projects are short term - one to two years - investments that can generate high yields. GLRCE periodically releases requests for proposals (RFPs) for these projects by posting them on the GLRCE website and by sending RFP invitational e-mails to all GLRCE Executive Board members and to all departmental heads of the Center's member institutions. Developmental projects may involve scientists within the RCE or may extend to appropriate regional scientists outside the Center. Applications are reviewed and rank-ordered by the Executive Board, endorsed by the GLRCE Scientific Advisory Board, and then approved by NIAID RCE Program Management. Criteria for the selection of proposals include, first, criteria related to Scientific merit, and, second, Center-related criteria, where the proposed work has the potential to: expand the scope and range of research of GLRCE;use or enhance existing GLRCE resources; expand the range of investigators and institutions involved in GLRCE;relate to the overall RCE themes;and, leverage resources and complement the Center's strengths. Progress of the Developmental Projects is closely monitored through monthly fiscal reporting, quarterly written progress reports, annual site visits, written annual reports/renewal applications as well as oral or poster presentations at the Center's annual meeting. The Executive Board and Scientific Advisory Board together with the GLRCE Administrative Core's support will terminate funding for developmental projects not demonstrating appropriate progress.

Public Health Relevance

Developmental projects are intended to expand the Center's portfolio of scientific researchers and research programs. In addition to projects with defined expectations, the Center needs to test exciting new ideas whose success is uncertain but that may generate quantum leaps of new information with translational opportunity. It is this type of investment that the Center seeks in Developmental Projects program.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center--Cooperative Agreements (U54)
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University of Chicago
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Schuld, Nathan J; Vervacke, Jeffrey S; Lorimer, Ellen L et al. (2014) The chaperone protein SmgGDS interacts with small GTPases entering the prenylation pathway by recognizing the last amino acid in the CAAX motif. J Biol Chem 289:6862-76
Sharma, Preeti; Wang, Ningyan; Kranz, David M (2014) Soluble T cell receptor V? domains engineered for high-affinity binding to staphylococcal or streptococcal superantigens. Toxins (Basel) 6:556-74
Pensinger, Daniel A; Aliota, Matthew T; Schaenzer, Adam J et al. (2014) Selective pharmacologic inhibition of a PASTA kinase increases Listeria monocytogenes susceptibility to ?-lactam antibiotics. Antimicrob Agents Chemother 58:4486-94
Becker, Russell E N; Berube, Bryan J; Sampedro, Georgia R et al. (2014) Tissue-specific patterning of host innate immune responses by Staphylococcus aureus ?-toxin. J Innate Immun 6:619-31
Schiano, Chelsea A; Koo, Jovanka T; Schipma, Matthew J et al. (2014) Genome-wide analysis of small RNAs expressed by Yersinia pestis identifies a regulator of the Yop-Ysc type III secretion system. J Bacteriol 196:1659-70
Stach, Christopher S; Herrera, Alfa; Schlievert, Patrick M (2014) Staphylococcal superantigens interact with multiple host receptors to cause serious diseases. Immunol Res 59:177-81
Lifshitz, Ziv; Burstein, David; Schwartz, Kierstyn et al. (2014) Identification of novel Coxiella burnetii Icm/Dot effectors and genetic analysis of their involvement in modulating a mitogen-activated protein kinase pathway. Infect Immun 82:3740-52
Merriman, Joseph A; Nemeth, Kimberly A; Schlievert, Patrick M (2014) Novel antimicrobial peptides that inhibit gram positive bacterial exotoxin synthesis. PLoS One 9:e95661
Schneewind, Olaf; Missiakas, Dominique (2014) Genetic manipulation of Staphylococcus aureus. Curr Protoc Microbiol 32:Unit 9C.3.
Wang, Ya-Ting; Missiakas, Dominique; Schneewind, Olaf (2014) GneZ, a UDP-GlcNAc 2-epimerase, is required for S-layer assembly and vegetative growth of Bacillus anthracis. J Bacteriol 196:2969-78

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