The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight founder mouse strains. We have recently genotyped 450 CC lines to provide the first accurate description of the genetic architecture of the CC population. We are now focused on making the largest number of lines accessible to the researchers as soon as possible through genotyping and re-derivation of CC lines nearing the thresholds for distribution (>90% inbred) and completion (>98% inbred). There are currently 27 CC lines in the distribution list and we expect to have a minimum of 50 CC lines by the end of 2012 and 100 CC lines by 2103. The CC is a Genetic Reference Population and, therefore, the number of lines available has a direct impact in the power of detecting loci with small to moderate effects and on the ability to select lines that are uniquely suited to specific research projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI057157-11
Application #
8437261
Study Section
Special Emphasis Panel (ZAI1-DDS-M)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
11
Fiscal Year
2013
Total Cost
$495,485
Indirect Cost
$80,576
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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