The Midwest Regional Center for Excellence in Biodefense and Emerging Infectious Diseases Research (MRCE) is a consortium of leading Midwest institutions that will serve the biodefense research and training needs for Region VII as well as parts of Ohio. The members of the MRCE are Washington University in St. Louis (site of the administrative core), Case Western Reserve University, Cleveland Clinic/Lerner Research Institute, the University of Iowa, St. Louis University, Kansas State University, Iowa State University, the Midwest Research Institute, and the University of Missouri. The major objective of the MRCE is to harness outstanding scientists from the best institutions to focus on critical issues in biodefense and emerging infectious diseases (EID). Our goal is research that will have an immediate impact on the nation's public health, and will provide the scientific base for a strong biodefense effort. During the previous funding period the MRCE transformed biodefense and EID research in Region VII by creating a highly collaborative research program that crossed institutions and led to seminal discoveries on poxviruses, West Nile Virus and plague. The new Strategic Plan for the MRCE centers on two research themes. Each has as their ultimate goal, improved biopreparedness for Region VII and the nation. One program centers on pathogen discovery, using state of the art sequencing approaches to identify new and previously unrecognized biologic threats. This work promises to help us "know our enemy", improving our ability to develop diagnostics and therapeutics against dangerous pathogens. To help develop countermeasures to these threats, we propose to delineate, at the molecular level, how the innate immune system controls pathogenic microorganisms. Our scientists will use this information to develop ways to stimulate endogenous host defenses that can protect against multiple biological threat agents. Resources supporting the MRCE Strategic Plan include the Washington University Genome Sequencing Center, the largest sequencing center in the United States, the new University of Missouri RBL facility, and new state of the art facilities for pathogen discovery. Finally, the MRCE will lead the effort to recruit new investigators to clinical and basic research in biodefense and train them in how to conduct this research safely and securely through four distinct Career Development Programs. The MRCE is uniquely positioned to serve Region VII and the nation through an exceptional program that addresses the most immediate and urgent national biodefense needs.

Public Health Relevance

This effort is relevant to public health because it deals with the threat of emerging infectious diseases or bioterrorist attacks. It directly addresses the goal of new diagnostics and new broad spectrum countermeasures for pathogens outlined in the NIAID Plan for Biodefense.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AI057160-10
Application #
8446477
Study Section
Special Emphasis Panel (ZAI1-DDS-M (J1))
Program Officer
Beanan, Maureen J
Project Start
2003-09-04
Project End
2014-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
10
Fiscal Year
2013
Total Cost
$6,494,175
Indirect Cost
$1,663,008
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Chen, Linxiao; Valentine, Jenny L; Huang, Chung-Jr et al. (2016) Outer membrane vesicles displaying engineered glycotopes elicit protective antibodies. Proc Natl Acad Sci U S A 113:E3609-18
Ulland, Tyler K; Jain, Nidhi; Hornick, Emma E et al. (2016) Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment. Nat Commun 7:13180
Miao, Chunhui; Li, Minghua; Zheng, Yi-Min et al. (2016) Cell-cell contact promotes Ebola virus GP-mediated infection. Virology 488:202-15
Zhao, Jincun; Vijay, Rahul; Zhao, Jingxian et al. (2016) MAVS Expressed by Hematopoietic Cells Is Critical for Control of West Nile Virus Infection and Pathogenesis. J Virol 90:7098-108
Lubman, Olga Y; Fremont, Daved H (2016) Parallel Evolution of Chemokine Binding by Structurally Related Herpesvirus Decoy Receptors. Structure 24:57-69
Markosyan, Ruben M; Miao, Chunhui; Zheng, Yi-Min et al. (2016) Induction of Cell-Cell Fusion by Ebola Virus Glycoprotein: Low pH Is Not a Trigger. PLoS Pathog 12:e1005373
Grinnage-Pulley, Tara; Mu, Yang; Dai, Lei et al. (2016) Dual Repression of the Multidrug Efflux Pump CmeABC by CosR and CmeR in Campylobacter jejuni. Front Microbiol 7:1097
Teijaro, John R; Studer, Sean; Leaf, Nora et al. (2016) S1PR1-mediated IFNAR1 degradation modulates plasmacytoid dendritic cell interferon-α autoamplification. Proc Natl Acad Sci U S A 113:1351-6
Grinnage-Pulley, Tara; Zhang, Qijing (2015) Genetic Basis and Functional Consequences of Differential Expression of the CmeABC Efflux Pump in Campylobacter jejuni Isolates. PLoS One 10:e0131534
Nukui, Masatoshi; Mori, Yasuko; Murphy, Eain A (2015) A human herpesvirus 6A-encoded microRNA: role in viral lytic replication. J Virol 89:2615-27

Showing the most recent 10 out of 325 publications