The MRCE Developmental Projects Program is designed to provide short-term support for innovative and high risk research on biodefense and EID. The Developmental Projects Program adds significant value to the MRCE Strategic Plan by: (1) supporting new investigators in the field of biodefense and emerging infectious diseases, or supporting outstanding established investigators who are moving their research into biodefense for the first time;(2) enabling the MRCE to refine and augment current themes, or develop alternative research themes-essentially a "farm club" for the strategic projects where nascent ideas can be groomed into full-blown multi-investigator research efforts. This is key for the flexibility of the MRCE in rapidly tailoring its research efforts to new regional/national needs;(3) supporting high-risk research in new areas where 1-2 years of funding may be sufficient to determine if the idea has merit, and may be competitive for funding from other sources;and (4) expanding the breadth of the MRCE research program and bringing new institutions into the MRCE and into the biodefense effort. We propose to fund six projects annually, with each receiving up to $100,000 in direct costs/yr. No project will receive more than 2 years of funding. Projects will be selected by the MRCE Steering Committee in a competition open to all qualified investigators from Region VII and Cleveland. To ensure maximum flexibility and to guarantee that the MRCE is always funding the best research, Developmental Programs are re-competed on a yearly basis. Developmental Projects may also leave the program because they receive extramural funding, or are promoted into a Strategic Projects.
The MRCE Developmental Projects plan is designed to identify emergent technology and new research opportunities. The key purpose of this program is to expand the scope and range of research, investigators and institutions involved in biodefense and EID research.
|Bandyopadhyay, Sarmistha; Long, Matthew E; Allen, Lee-Ann H (2014) Differential expression of microRNAs in Francisella tularensis-infected human macrophages: miR-155-dependent downregulation of MyD88 inhibits the inflammatory response. PLoS One 9:e109525|
|Virgin, Herbert W (2014) The virome in mammalian physiology and disease. Cell 157:142-50|
|Bialasiewicz, Seweryn; McVernon, Jodie; Nolan, Terry et al. (2014) Detection of a divergent Parainfluenza 4 virus in an adult patient with influenza like illness using next-generation sequencing. BMC Infect Dis 14:275|
|Rasmussen, Jed A; Post, Deborah M B; Gibson, Bradford W et al. (2014) Francisella tularensis Schu S4 lipopolysaccharide core sugar and O-antigen mutants are attenuated in a mouse model of tularemia. Infect Immun 82:1523-39|
|Patel, Dhara A; Patel, Anand C; Nolan, William C et al. (2014) High-throughput screening normalized to biological response: application to antiviral drug discovery. J Biomol Screen 19:119-30|
|Rohatgi, Anjali; Corbo, Joseph C; Monte, Kristen et al. (2014) Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus. J Virol 88:2414-25|
|Ermler, Megan E; Traylor, Zachary; Patel, Krupen et al. (2014) Rift Valley fever virus infection induces activation of the NLRP3 inflammasome. Virology 449:174-80|
|Moorman, Nathaniel J; Murphy, Eain A (2014) Roseomics: a blank slate. Curr Opin Virol 9:188-93|
|Canny, Susan P; Reese, Tiffany A; Johnson, L Steven et al. (2014) Pervasive transcription of a herpesvirus genome generates functionally important RNAs. MBio 5:e01033-13|
|Barker, Jason H; Kaufman, Justin W; Zhang, De-Sheng et al. (2014) Metabolic labeling to characterize the overall composition of Francisella lipid A and LPS grown in broth and in human phagocytes. Innate Immun 20:88-103|
Showing the most recent 10 out of 257 publications