An integrated genomic approach is a powerful way of identifying functionally important genes and pathways that mediate the progression to active TB in HIV co-infection. This molecular insight is critical to the future development of viable strategies and therapies aimed at minimizing the significant clinical impact of active TB disease in HIV co-infected children. This project will train local researchers in the use of newer RNA technologies and statistical analyses that will complement and extend the efforts of CAfGEN to build longterm, sustainable, local genomic capacity that runs the gamut from data production to analysis.
| Retshabile, Gaone; Mlotshwa, Busisiwe C; Williams, Lesedi et al. (2018) Whole-Exome Sequencing Reveals Uncaptured Variation and Distinct Ancestry in the Southern African Population of Botswana. Am J Hum Genet 102:731-743 |
| Mlotshwa, Busisiwe C; Mwesigwa, Savannah; Mboowa, Gerald et al. (2017) The collaborative African genomics network training program: a trainee perspective on training the next generation of African scientists. Genet Med 19:826-833 |
| Mokone, Gaonyadiwe G; Kebaetse, Maikutlo; Wright, John et al. (2014) Establishing a new medical school: Botswana's experience. Acad Med 89:S83-7 |
| H3Africa Consortium (see original citation for additional authors) (2014) Research capacity. Enabling the genomic revolution in Africa. Science 344:1346-8 |
