The Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR) Pilot/Demonstration Clinical Research Projects Program will support new ideas that have potential to create and/or change paradigms concerning eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), and eosinophilic colitis (EC). We plan to support up to two Pilot/Demonstration Clinical Research Projects each year. The Pilot/Demonstration Clinical Research Projects will last up to two years and ideally take maximum advantage of new clinical research opportunities in investigating EoE, EG, and EC. The projects may be collaborative among investigators within one or more CEGIR sites or with investigators outside the CEGIR environment. We have already identified over ten exciting and cutting-edge projects that could become Pilot/Demonstration Clinical Research Projects, and a process for optimally identifying, selecting, and carrying out these projects is described.

Public Health Relevance

The Pilot/Demonstration Clinical Research Projects Program will support research projects that encourage the development of new ideas concerning eosinophilic esophagitis, eosinophilic gastritis, and eosinophilic colitis. Projects will be selected by their likelihood to develop new models and ideas that will improve the way researchers, healthcare providers, and patients understand these diseases and to develop better treatments.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZTR1-CI-8 (01))
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Cincinnati Children's Hospital Medical Center
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Molina-Infante, Javier; Bredenoord, Albert J; Cheng, Edaire et al. (2016) Proton pump inhibitor-responsive oesophageal eosinophilia: an entity challenging current diagnostic criteria for eosinophilic oesophagitis. Gut 65:524-31
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Gonsalves, Nirmala; Furuta, Glenn T; Atkins, Dan (2016) Eosinophilic Gastrointestinal Disorders Affect More Than Just the Esophagus. J Pediatr Gastroenterol Nutr 62:1-2
Nguyen, Nathalie; Furuta, Glenn T; Masterson, Joanne C (2016) Deeper Than the Epithelium: Role of Matrix and Fibroblasts in Pediatric and Adult Eosinophilic Esophagitis. J Pediatr Gastroenterol Nutr 63:168-9
Rawson, Renee; Yang, Tom; Newbury, Robert O et al. (2016) TGF-β1-induced PAI-1 contributes to a profibrotic network in patients with eosinophilic esophagitis. J Allergy Clin Immunol 138:791-800.e4

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