The training and education core will serve three main functions: (1) Integrate existing and newly developed basic science and clinical training activities within and among the four participating institutions by using interactive web-based applications. Didactic seminars and hands-on workshops on muscle disease topics will be conducted regularly at each institution that emphasize state-of-the-art assessments of muscle biology, disease mechanisms and potential clinical applications. Video recording these events will permit posting on the Center website for access by the general public. (2) Train, mentor, and sponsor predoctoral, postdoctoral, and clinical trainees in the science and clinical investigation of muscle disease. The goal is to train highly qualified junior clinicians and scientists and prepare them to succeed as independent investigators in this field. Trainees will receive training in the ethical treatment of animals and human subjects, proper research methodology, grant and manuscript writing, and public speaking skills. Each trainee will be mentored in a highly structured format with regular feedback and early correction of any deficiencies. (3) Link to U.S. and international advocacy groups, e.g. Muscular Dystrophy Association, Parent Project MD in US and UK, for muscle diseases to establish a conduit for information from the Centers to be disseminated into the public domain and for two-way communication of issues from the public back to the Center for consideration. This structure will enhance public awareness and understanding of complex muscle disease topics and allow the Center's members to keep current with issues of importance to the public. The overarching goal of this Wellstone Center's education core is to provide promising young physicians and scientists with closely supervised, rigorous training in basic and patient-oriented research, and methods in muscle diseases. This will prepare the next generation of basic and physician scientists to tackle the complexities and challenaes of curino muscular dvstroohies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AR052646-08
Application #
8381355
Study Section
Special Emphasis Panel (ZNS1-SRB-S)
Project Start
2012-08-01
Project End
2015-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
8
Fiscal Year
2012
Total Cost
$210,673
Indirect Cost
$52,489
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Quattrocelli, Mattia; Spencer, Melissa J; McNally, Elizabeth M (2017) Outside in: The matrix as a modifier of muscular dystrophy. Biochim Biophys Acta 1864:572-579
Quattrocelli, Mattia; Barefield, David Y; Warner, James L et al. (2017) Intermittent glucocorticoid steroid dosing enhances muscle repair without eliciting muscle atrophy. J Clin Invest 127:2418-2432
McNally, Elizabeth M (2017) Cardiomyopathy in Muscular Dystrophy: When to Treat? JAMA Cardiol 2:199
Hammers, David W; Merscham-Banda, Melissa; Hsiao, Jennifer Ying et al. (2017) Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med 9:531-544
Demonbreun, Alexis R; McNally, Elizabeth M (2017) Muscle cell communication in development and repair. Curr Opin Pharmacol 34:7-14
Kim, Ellis Y; Page, Patrick; Dellefave-Castillo, Lisa M et al. (2016) Direct reprogramming of urine-derived cells with inducible MyoD for modeling human muscle disease. Skelet Muscle 6:32
Capote, Joana; Kramerova, Irina; Martinez, Leonel et al. (2016) Osteopontin ablation ameliorates muscular dystrophy by shifting macrophages to a pro-regenerative phenotype. J Cell Biol 213:275-88
Kramerova, Irina; Ermolova, Natalia; Eskin, Ascia et al. (2016) Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy). Hum Mol Genet 25:2194-2207
Quattrocelli, Mattia; McNally, Elizabeth M (2016) BMP and WNT: the road to cardiomyocytes is paved with precise modulation. Stem Cell Investig 3:21
Demonbreun, Alexis R; Quattrocelli, Mattia; Barefield, David Y et al. (2016) An actin-dependent annexin complex mediates plasma membrane repair in muscle. J Cell Biol 213:705-18

Showing the most recent 10 out of 127 publications