The training and education core will serve three main functions: (1) Integrate existing and newly developed basic science and clinical training activities within and among the four participating institutions by using interactive web-based applications. Didactic seminars and hands-on workshops on muscle disease topics will be conducted regularly at each institution that emphasize state-of-the-art assessments of muscle biology, disease mechanisms and potential clinical applications. Video recording these events will permit posting on the Center website for access by the general public. (2) Train, mentor, and sponsor predoctoral, postdoctoral, and clinical trainees in the science and clinical investigation of muscle disease. The goal is to train highly qualified junior clinicians and scientists and prepare them to succeed as independent investigators in this field. Trainees will receive training in the ethical treatment of animals and human subjects, proper research methodology, grant and manuscript writing, and public speaking skills. Each trainee will be mentored in a highly structured format with regular feedback and early correction of any deficiencies. (3) Link to U.S. and international advocacy groups, e.g. Muscular Dystrophy Association, Parent Project MD in US and UK, for muscle diseases to establish a conduit for information from the Centers to be disseminated into the public domain and for two-way communication of issues from the public back to the Center for consideration. This structure will enhance public awareness and understanding of complex muscle disease topics and allow the Center's members to keep current with issues of importance to the public. The overarching goal of this Wellstone Center's education core is to provide promising young physicians and scientists with closely supervised, rigorous training in basic and patient-oriented research, and methods in muscle diseases. This will prepare the next generation of basic and physician scientists to tackle the complexities and challenges of curing muscular dystrophies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AR052646-10
Application #
8722307
Study Section
Special Emphasis Panel (ZNS1-SRB-S)
Project Start
Project End
Budget Start
2014-08-01
Budget End
2015-07-31
Support Year
10
Fiscal Year
2014
Total Cost
$184,702
Indirect Cost
$61,444
Name
University of Pennsylvania
Department
Type
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Smith, Lucas R; Barton, Elisabeth R (2018) Regulation of fibrosis in muscular dystrophy. Matrix Biol 68-69:602-615
Hicks, Michael R; Hiserodt, Julia; Paras, Katrina et al. (2018) ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol 20:46-57
Barnard, Alison M; Willcocks, Rebecca J; Finanger, Erika L et al. (2018) Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy. PLoS One 13:e0194283
Fallon, Justin R; McNally, Elizabeth M (2018) Non-Glycanated Biglycan and LTBP4: Leveraging the extracellular matrix for Duchenne Muscular Dystrophy therapeutics. Matrix Biol 68-69:616-627
Batra, Abhinandan; Harrington, Ann; Lott, Donovan J et al. (2018) Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy. Am J Phys Med Rehabil 97:734-740
Daniel, Bence; Nagy, Gergely; Czimmerer, Zsolt et al. (2018) The Nuclear Receptor PPAR? Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory. Immunity 49:615-626.e6
Willcocks, Rebecca J; Triplett, William T; Lott, Donovan J et al. (2018) Leg muscle MRI in identical twin boys with duchenne muscular dystrophy. Muscle Nerve :
Aartsma-Rus, Annemieke; Ferlini, Alessandra; McNally, Elizabeth M et al. (2018) 226th ENMC International Workshop:: Towards validated and qualified biomarkers for therapy development for Duchenne muscular dystrophy 20-22 January 2017, Heemskerk, The Netherlands. Neuromuscul Disord 28:77-86
Barthélémy, Florian; Defour, Aurélia; Lévy, Nicolas et al. (2018) Muscle Cells Fix Breaches by Orchestrating a Membrane Repair Ballet. J Neuromuscul Dis 5:21-28
Hammers, David W; Merscham-Banda, Melissa; Hsiao, Jennifer Ying et al. (2017) Supraphysiological levels of GDF11 induce striated muscle atrophy. EMBO Mol Med 9:531-544

Showing the most recent 10 out of 142 publications