The UMDNJ/Rutgers University CounterACT Research Center of Excellence has established a multidisciplinary Training and Education Core directed at undergraduate, graduate, and postdoctoral educational programs as well as health care providers at Rutgers University School of Pharmacy, the School's of Public Health at UMDNJ and New York Medical College, UMDNJ-Robert Wood Johnson Medical School, the UMDNJ-Cancer Institute of New Jersey, and the Health Sciences Program at Lehigh University. Acfivifies in the Core have been highly successful over the last grant period and have included seminars, symposia, distance education programs and directed laboratory modules. Highlights over the last grant period: a). Over 60 undergraduates have taken our CounterACT sponsored Freshman seminar series """"""""Threat of Exposure to Chemical and Biological Warfare Agents"""""""". b). Nine doctoral students and six post-doctoral fellows are working full time with CounterACT investigators on projects directly related to chemical threat agents. Based on work thus far, one postdoctoral fellow (Yi-Hua Jan) was awarded her own NIH NRSA postdoctoral fellowship (""""""""Mechanisms of Sulfur Mustard Toxicology"""""""", F32ES017389) and one student (Sree Anumolu) received her Ph.D. in Pharmaceufics in 2010 (thesis: """"""""Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced wounds""""""""). Sixteen undergraduates and five graduate students have rotated in CounterACT investigator laboratories (posted on our website, www.CounterACT.rutgers.edu) to learn assays, methods, and animal models that are ongoing in CounterACT Center member laboratories. c). A freely available webinar series and a searchable reference library containing over 4,000 citafions with PMID links on sulfur mustard and related threat agents were put into place on our webcite. Center investigators have also established an online distance education course on chemical and biological terrorism. d). A well attended seminar series and a weekly journal club on Bioterrorism was established at Rutgers University/UMDNJ-Robert Wood Johnson Medical School. e). CounterACT Center investigators organized the 4""""""""^ international conference on Oxidative/Nitrosative Stress and Disease (October 28-30, 2009), a meeting sponsored by the New York Academy of Sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54AR055073-07
Application #
8382009
Study Section
Special Emphasis Panel (ZRG1-MDCN-J)
Project Start
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
7
Fiscal Year
2012
Total Cost
$339,112
Indirect Cost
Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
617022384
City
Piscataway
State
NJ
Country
United States
Zip Code
08854
Moretti, Alysha; Li, Qi; Chmielowski, Rebecca et al. (2018) Nanotherapeutics Containing Lithocholic Acid-Based Amphiphilic Scorpion-Like Macromolecules Reduce In Vitro Inflammation in Macrophages: Implications for Atherosclerosis. Nanomaterials (Basel) 8:
Szilagyi, John T; Fussell, Karma C; Wang, Yun et al. (2018) Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol Appl Pharmacol 359:102-107
Joseph, Laurie B; Composto, Gabriella M; Perez, Roberto M et al. (2018) Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett 293:77-81
Chang, Yoke-Chen; Gordon, Marion K; Gerecke, Donald R (2018) Expression of Laminin 332 in Vesicant Skin Injury and Wound Repair. Clin Dermatol (Wilmington) 2:
Yang, Shaojun; Jan, Yi-Hua; Mishin, Vladimir et al. (2017) Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. Chem Res Toxicol 30:1406-1418
Venosa, Alessandro; Gow, James G; Hall, LeRoy et al. (2017) Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor. Toxicol Sci 157:222-234
Francis, Mary; Sun, Richard; Cervelli, Jessica A et al. (2017) Editor's Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury. Toxicol Sci 155:182-195
Chmielowski, Rebecca A; Abdelhamid, Dalia S; Faig, Jonathan J et al. (2017) Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation. Acta Biomater 57:85-94
Francis, Mary; Groves, Angela M; Sun, Richard et al. (2017) Editor's Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure. Toxicol Sci 155:474-484
Malaviya, Rama; Laskin, Jeffrey D; Laskin, Debra L (2017) Anti-TNF? therapy in inflammatory lung diseases. Pharmacol Ther 180:90-98

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