The UMDNJ/Rutgers University CounterACT Research Center of Excellence has established a multidisciplinary Training and Education Core directed at undergraduate, graduate, and postdoctoral educational programs as well as health care providers at Rutgers University School of Pharmacy, the School's of Public Health at UMDNJ and New York Medical College, UMDNJ-Robert Wood Johnson Medical School, the UMDNJ-Cancer Institute of New Jersey, and the Health Sciences Program at Lehigh University. Acfivifies in the Core have been highly successful over the last grant period and have included seminars, symposia, distance education programs and directed laboratory modules. Highlights over the last grant period: a). Over 60 undergraduates have taken our CounterACT sponsored Freshman seminar series "Threat of Exposure to Chemical and Biological Warfare Agents". b). Nine doctoral students and six post-doctoral fellows are working full time with CounterACT investigators on projects directly related to chemical threat agents. Based on work thus far, one postdoctoral fellow (Yi-Hua Jan) was awarded her own NIH NRSA postdoctoral fellowship ("Mechanisms of Sulfur Mustard Toxicology", F32ES017389) and one student (Sree Anumolu) received her Ph.D. in Pharmaceufics in 2010 (thesis: "Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced wounds"). Sixteen undergraduates and five graduate students have rotated in CounterACT investigator laboratories (posted on our website, to learn assays, methods, and animal models that are ongoing in CounterACT Center member laboratories. c). A freely available webinar series and a searchable reference library containing over 4,000 citafions with PMID links on sulfur mustard and related threat agents were put into place on our webcite. Center investigators have also established an online distance education course on chemical and biological terrorism. d). A well attended seminar series and a weekly journal club on Bioterrorism was established at Rutgers University/UMDNJ-Robert Wood Johnson Medical School. e). CounterACT Center investigators organized the 4"^ international conference on Oxidative/Nitrosative Stress and Disease (October 28-30, 2009), a meeting sponsored by the New York Academy of Sciences.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-MDCN-J)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Rbhs-Robert Wood Johnson Medical School
United States
Zip Code
Malaviya, Rama; Laskin, Jeffrey D; Laskin, Debra L (2014) Oxidative stress-induced autophagy: role in pulmonary toxicity. Toxicol Appl Pharmacol 275:145-51
Joseph, Laurie B; Heck, Diane E; Cervelli, Jessica A et al. (2014) Structural changes in hair follicles and sebaceous glands of hairless mice following exposure to sulfur mustard. Exp Mol Pathol 96:316-27
Massa, Christopher B; Scott, Pamela; Abramova, Elena et al. (2014) Acute chlorine gas exposure produces transient inflammation and a progressive alteration in surfactant composition with accompanying mechanical dysfunction. Toxicol Appl Pharmacol 278:53-64
Mishin, Vladimir; Heck, Diane E; Laskin, Debra L et al. (2014) Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions. Toxicol Sci 141:344-52
Zheng, Ruijin; Heck, Diane E; Black, Adrienne T et al. (2014) Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid. Free Radic Biol Med 67:1-9
Pinkerton, Nathalie M; Zhang, Stacey W; Youngblood, Richard L et al. (2014) Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery. Biomacromolecules 15:252-61
Jan, Yi-Hua; Heck, Diane E; Dragomir, Ana-Cristina et al. (2014) Acetaminophen reactive intermediates target hepatic thioredoxin reductase. Chem Res Toxicol 27:882-94
Page, Eric J; Gray, Joshua P (2014) Agents of Bioterrorism: Curriculum and Pedagogy in an Online Masters Course. J Toxicol Educ 1:31-53
Chang, Yoke-Chen; Wang, James D; Hahn, Rita A et al. (2014) Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. Toxicol Appl Pharmacol 280:236-44
Chen, Peiming; Zhang, Xiaoping; Jia, Lee et al. (2014) Optimal structural design of mannosylated nanocarriers for macrophage targeting. J Control Release 194:341-9

Showing the most recent 10 out of 90 publications