The Statistical Core plays a central role in the functioning of the Immunologic Monitoring Consortium (IMC). Statistical collaboration is required in assay development, comparison, and in the design and execution of the clinical trials that will serve to validate the ability of developed assays to monitor immune responses. The statistical core will work with the administrative core to develop the website to be used as a data repository and will work with each project to perform all the analyses at the pre-clinical and clinical levels. The specific functions of the statistical core are to: (1) assess the reproducibility of the methodologies developed in the four projects and to estimate properties of assay results in volunteers and in cancer patients, (2) assess immune augmentation after immunization, (3) assess the degree of agreement among the four assays, ( 4) provide design and analysis of immunization studies in animals to assess correlation of immune response with anti-tumor activity, and, (5) provide design and analysis of clinical trials of vaccines in cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA090818-02
Application #
6563978
Study Section
Special Emphasis Panel (ZCA1)
Project Start
2002-02-19
Project End
2002-12-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2002
Total Cost
$296,752
Indirect Cost
Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
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Goodell, Vivian; dela Rosa, Corazon; Slota, Meredith et al. (2007) Sensitivity and specificity of tritiated thymidine incorporation and ELISPOT assays in identifying antigen specific T cell immune responses. BMC Immunol 8:21

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