This is a resubmission for The University of Puerto Rico Comprehensive Cancer Center (UPRCCC) and The University of Texas M. D. Anderson Cancer Center (MDACC) Partnership for Excellence in Research Grant, which addresses comments and recommendations from the 1) summary statement, 2) NCI Site Visit, and 3) IAC and PSC Committees. Areas strengthened in this application include: leadership, communication, committee oversight, evaluation, career development and mentorship. Funds granted in this award will be used to: 1) support 3 full projects in cancer biology and prevention and 1 pilot project in epidemiology, 2) enhance existing collaborations and establish new collaborations, 3) increase faculty/trainee participation in the training program, 4) expand efforts in our Outreach Program to impact a larger audience, and 5) fortify and stabilize the infrastructure developing at the UPRCCC. Research grants included target 1) developing new cancer imaging techniques, 2) regulating RNA in eukaryotic cells, 3) reducing cancer risk through combined alcohol and tobacco treatment and 4) assessing the role of insulin resistance syndrome as a risk factor for endometrial cancer. The Outreach Program, which was added into the original grant mid-year 3, has been expanded to include cancer related to tobacco, as well as breast, cervical and HPV. The Training Program has also been expanded in scope to impact more faculty and trainees through a comprehensive career development and mentorship training program. The original grant (2002) was awarded to establish a comprehensive long-term mutually beneficial relationship to target and eradicate cancer health disparities. The two short term objectives of the original application were met: 1) develop independent cancer research investigators and 2) establish a strong working relationship based on mutual benefit, identified strengths and reciprocity. The 3rd long-term objective of the Partnership is to regain NCI-designation for the UPRCCC. Thus far, the Partnership has set the foundation for a dynamic collaboration dedicated to enhancing each partner's strengths and eliminating each partner's weaknesses. The Partnership has also served as the catalyst for two major laws passed in Puerto Rico, one of which resulted in the allocation of funding for establishing the infrastructure and recruiting top notch faculty to the UPRCCC. As of 2008, the Partnership is far from reaching its long-range goal of regaining NCI-designation for the UPRCCC. Funding for the U54 resubmission is critical to maintain the momentum of the Partnership's joint efforts in Cancer Research, Training and Outreach.

Public Health Relevance

This resubmission seeks to foster and support an existing collaboration between the UPRCCC and MDACC. By addressing the differences in incidence, prevalence, mortality, and burden of cancer that exist among Hispanic populations in the US, the Partnership will strive to reduce these differences through efforts in Research, Outreach, and Training. Partnership contributions will also aid in building a stronger national cancer program through the development of a pipeline of well-trained, Hispanic cancer researchers.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54CA096297-10S1
Application #
8537559
Study Section
Special Emphasis Panel (ZCA1-SRRB-K (O1))
Program Officer
Moten, Carmen P
Project Start
2002-08-16
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
10
Fiscal Year
2012
Total Cost
$202,000
Indirect Cost
$66,430
Name
University of Puerto Rico Med Sciences
Department
Type
DUNS #
948108063
City
San Juan
State
PR
Country
United States
Zip Code
00936
Canner, Judith E; McEligot, Archana J; Pérez, María-Eglée et al. (2017) Enhancing Diversity in Biomedical Data Science. Ethn Dis 27:107-116
Mama, Scherezade K; Song, Jaejoon; Ortiz, Alexis et al. (2017) Longitudinal social cognitive influences on physical activity and sedentary time in Hispanic breast cancer survivors. Psychooncology 26:214-221
Banerjee, Dipak K; Zhang, Zhenbo; Baksi, Krishna et al. (2017) Dolichol phosphate mannose synthase: a Glycosyltransferase with Unity in molecular diversities. Glycoconj J 34:467-479
Cruz-Correa, Marcia; Pérez-Mayoral, Julyann; Dutil, Julie et al. (2017) Hereditary cancer syndromes in Latino populations: genetic characterization and surveillance guidelines. Hered Cancer Clin Pract 15:3
Salgado-Montilla, Jeannette L; Rodríguez-Cabán, Jorge L; Sánchez-García, Jonathan et al. (2017) Impact of FTO SNPs rs9930506 and rs9939609 in Prostate Cancer Severity in a Cohort of Puerto Rican Men. Arch Cancer Res 5:
Correa-Fernández, Virmarie; Díaz-Toro, Elba C; Reitzel, Lorraine R et al. (2017) Combined treatment for at-risk drinking and smoking cessation among Puerto Ricans: A randomized clinical trial. Addict Behav 65:185-192
Ballista-Hernández, Joan; Martínez-Ferrer, Margaly; Vélez, Roman et al. (2017) Mitochondrial DNA Integrity Is Maintained by APE1 in Carcinogen-Induced Colorectal Cancer. Mol Cancer Res 15:831-841
Irizarry-Ramírez, Margarita; Kittles, Rick A; Wang, Xuemei et al. (2017) Genetic ancestry and prostate cancer susceptibility SNPs in Puerto Rican and African American men. Prostate 77:1118-1127
Cruz-Correa, Marcia; Pérez-Mayoral, Julyann; Dutil, Julie et al. (2017) Clinical Cancer Genetics Disparities among Latinos. J Genet Couns 26:379-386
Serra, Yolanda A; Colón-López, Vivian; Savas, Lara S et al. (2017) Using Intervention Mapping to Develop Health Education Components to Increase Colorectal Cancer Screening in Puerto Rico. Front Public Health 5:324

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