Breast tumors display remarkable biological and clinical heterogeneity as covered extensively in the Introduction and Progress Report. Developing a better understanding of the molecular basis of such heterogeneity is central to the goal of rational, individualized treatment for patients based on molecular profiling. A large number of pathways, including RTKs, RAF/MEK/ERK, AKT, NFKB, JAK/STAT, JNK, p38, etc. work to control diverse cellular processes. In cancer the aberrant activity of the system is responsible for proliferation, apoptosis and other "hallmarks of cancer". Diverse open questions concerning both the basic biology of cancer signaling and related therapeutic implications are rooted in tumor-specific network connectivity. The need to elucidate such tumor specific connectivity motivates the broad goals of this project.

Agency
National Institute of Health (NIH)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA112970-10
Application #
8629530
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Oregon Health and Science University
Department
Type
DUNS #
City
Portland
State
OR
Country
United States
Zip Code
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