N2. Administrative Core Overview Five years of experience in overseeing a U54 Integrative Cancer Biology Center has provided critical insights into the complexities of organizing a structure with a high degree of interplay between investigators from various disciplines and across multiple Institutions. These insights on decisions of scientific directions and prioritization of tasks, allocation and reallocation of resources, communication strategies, and integration strategies have been taken into consideration when implementing a plan for the current application. Description and Goals The main functions of the Administrative Core facility will be to: 1) provide administrative support, 2) promote synergistic interactions among the Core facilities. Components and the Projects, 3) promote multidisciplinary interactions between investigators, 4) facilitate dissemination of data to other programs in the CCSB, 5) facilitate aspects of the Education, Training &Outreach Component, 6) coordinate visits from the External Advisory Board, and 7) provide fiscal and financial accountability and aid in promoting cost-effective management.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA113007-09
Application #
8449526
Study Section
Special Emphasis Panel (ZCA1-SRLB-C)
Project Start
Project End
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
9
Fiscal Year
2013
Total Cost
$115,966
Indirect Cost
$20,491
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Hardeman, Keisha N; Peng, Chengwei; Paudel, Bishal B et al. (2017) Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition. Sci Rep 7:42604
Udyavar, Akshata R; Wooten, David J; Hoeksema, Megan et al. (2017) Novel Hybrid Phenotype Revealed in Small Cell Lung Cancer by a Transcription Factor Network Model That Can Explain Tumor Heterogeneity. Cancer Res 77:1063-1074
Harris, Leonard A; Frick, Peter L; Garbett, Shawn P et al. (2016) An unbiased metric of antiproliferative drug effect in vitro. Nat Methods 13:497-500
Franco, Omar E; Tyson, Darren R; Konvinse, Katherine C et al. (2016) Altered TGF-?/? signaling drives cooperation between breast cancer cell populations. FASEB J 30:3441-3452
Werner, Benjamin; Scott, Jacob G; Sottoriva, Andrea et al. (2016) The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer Res 76:1705-13
Gerlee, Philip; Kim, Eunjung; Anderson, Alexander R A (2015) Bridging scales in cancer progression: mapping genotype to phenotype using neural networks. Semin Cancer Biol 30:30-41
Frick, Peter L; Paudel, Bishal B; Tyson, Darren R et al. (2015) Quantifying heterogeneity and dynamics of clonal fitness in response to perturbation. J Cell Physiol 230:1403-12
Nichol, Daniel; Jeavons, Peter; Fletcher, Alexander G et al. (2015) Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance. PLoS Comput Biol 11:e1004493
Broussard, Joshua A; Diggins, Nicole L; Hummel, Stephen et al. (2015) Automated analysis of cell-matrix adhesions in 2D and 3D environments. Sci Rep 5:8124
Enderling, Heiko (2015) Cancer stem cells: small subpopulation or evolving fraction? Integr Biol (Camb) 7:14-23

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