During the last 5 years, as we learned how to integrate experimentation with the single mathematical model (HDC) we originally focused on, we gradually expanded into other types of models. We have developed a suite of mathematical and computational models that consider different spatial and temporal scales of tumor progression, so that their application is dictated by a specific biological question. The resolution and scope of each model is largely driven by the specific aspect of tumor progression we are considering in the Projects.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-C)
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Vanderbilt University Medical Center
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Gallaher, Jill; Babu, Aravind; Plevritis, Sylvia et al. (2014) Bridging population and tissue scale tumor dynamics: a new paradigm for understanding differences in tumor growth and metastatic disease. Cancer Res 74:426-35
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Basanta, D; Scott, J G; Fishman, M N et al. (2012) Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game. Br J Cancer 106:174-81
Kam, Yoonseok; Rejniak, Katarzyna A; Anderson, Alexander R A (2012) Cellular modeling of cancer invasion: integration of in silico and in vitro approaches. J Cell Physiol 227:431-8

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