During the last 5 years, as we learned how to integrate experimentation with the single mathematical model (HDC) we originally focused on, we gradually expanded into other types of models. We have developed a suite of mathematical and computational models that consider different spatial and temporal scales of tumor progression, so that their application is dictated by a specific biological question. The resolution and scope of each model is largely driven by the specific aspect of tumor progression we are considering in the Projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA113007-10
Application #
8628761
Study Section
Special Emphasis Panel (ZCA1-SRLB-C)
Project Start
Project End
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
10
Fiscal Year
2014
Total Cost
$375,208
Indirect Cost
$29,862
Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Gallaher, Jill; Babu, Aravind; Plevritis, Sylvia et al. (2014) Bridging population and tissue scale tumor dynamics: a new paradigm for understanding differences in tumor growth and metastatic disease. Cancer Res 74:426-35
Scott, Jacob G; Hjelmeland, Anita B; Chinnaiyan, Prakash et al. (2014) Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity. PLoS Comput Biol 10:e1003433
Poleszczuk, Jan; Enderling, Heiko (2014) A High-Performance Cellular Automaton Model of Tumor Growth with Dynamically Growing Domains. Appl Math (Irvine) 5:144-152
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Bryce, Nicole S; Reynolds, Albert B; Koleske, Anthony J et al. (2013) WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl. PLoS One 8:e64533
Rejniak, Katarzyna A; Quaranta, Vito; Anderson, Alexander R A (2012) Computational investigation of intrinsic and extrinsic mechanisms underlying the formation of carcinoma. Math Med Biol 29:67-84
Basanta, D; Scott, J G; Fishman, M N et al. (2012) Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game. Br J Cancer 106:174-81
Kam, Yoonseok; Rejniak, Katarzyna A; Anderson, Alexander R A (2012) Cellular modeling of cancer invasion: integration of in silico and in vitro approaches. J Cell Physiol 227:431-8

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