Cancer is one of the most serious diseases in man and the second most fatal disease, after atherosclerosis. Breast cancer is the most common cancer among African American women, Recently, interest in herbal extracts for the prevention and treatment of this disease has increased, for such extracts are considered to be safe, economically feasible, and effective. Withania somnifera (WS), commonly known as ashwagandha, has been used for many years in traditional medicine, especially in the treatment of human tumors, arthritis, and stress. This small, woody shrub, which grows about two feet in height, is found in Africa, the Mediterranean, India, and the United States, where it is known as winter cherry. Preliminary data from our laboratory, obtained on a previous pilot project, funded by the MSM/TU/UAB CCC Partnership, show that daily administration of a root extract of WS (given as an oral dose of 300 mg/kg for 21 days) causes 99% grovrth inhibition of breast cancer cells xenografted in mice. The main goal of this proposal is to determine a safe and efficacious dose of WS for use in rats for chemoprevention in methylnitrosourea (MNU)-induced mammary tumors and in mice for therapy of xenografted breast cancer cells. In addition, the effect of the WS root extract, alone and in combination with tamoxifen, will be evaluated in a panel of breast cancer cell lines in vitro. The molecular effects of WS extract will be evaluated by using slices of tumors obtained from treated animals and breast cancer cells exposed to the extract.
This Study could provide a basis for the clinical use of a safe and efficacious anti-tumor drug. By reducing the doses of standard drugs and the cost of treatment, such a drug could provide effective therapy and also reduce the suffering of breast cancer patients caused by the side effects of currently used anti-cancer medicines and treatments.
|Tabatabai, Mohammad A; Kengwoung-Keumo, Jean-Jacques; Oates, Gabriela R et al. (2016) Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis. PLoS One 11:e0162949|
|Akinyemiju, Tomi; Meng, Qingrui; Vin-Raviv, Neomi (2016) Association between body mass index and in-hospital outcomes: Analysis of the nationwide inpatient database. Medicine (Baltimore) 95:e4189|
|Wang, Honghe; Liu, Wei; Black, ShaNekkia et al. (2016) Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. Oncotarget 7:5677-89|
|Fouad, Mona N; Acemgil, Aras; Bae, Sejong et al. (2016) Patient Navigation As a Model to Increase Participation of African Americans in Cancer Clinical Trials. J Oncol Pract 12:556-63|
|Kamal, Arif H; Dionne-Odom, J Nicholas (2016) A Blue Ocean Strategy for Palliative Care: Focus on Family Caregivers. J Pain Symptom Manage 51:e1-3|
|Li, Rong; Zhang, Kui; Penedo, Thuy Linh et al. (2016) The RANK Pathway in Advanced Breast Cancer: Does Src Play a Role? Appl Immunohistochem Mol Morphol 24:42-50|
|Dionne-Odom, J Nicholas; Hull, Jay G; Martin, Michelle Y et al. (2016) Associations between advanced cancer patients' survival and family caregiver presence and burden. Cancer Med 5:853-62|
|Okwali, Michelle; Greenlee, Heather; Ginindza, Themba et al. (2016) Adherence to cancer prevention guidelines in South Africa is associated with health care access. Int Health 8:211-9|
|Costas, Laura; Lambert, Brice H; Birmann, Brenda M et al. (2016) A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. Cancer Epidemiol Biomarkers Prev 25:217-21|
|Jones, Jacqueline; Mukherjee, Angana; Karanam, Balasubramanyam et al. (2016) African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression. Cancer Lett 380:513-22|
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