The UAB Cancer Outreach Program of the MSM/TU/UAB Partnership seeks to increase the accrual of African Americans into cancer clinical trials. Its goals are to 1) train Community Health Advisors (CHAs) as patient navigators to assist African American cancer patients overcome barriers to participation in cancer clinical trials;2) increase the recruitment and retention of African American cancer patients in therapeutic cancer clinical trials at UAB and Cooper Green Mercy Hospital (CGMH);3) develop and implement a culturally appropriate awareness of clinical trials and an educational program targeting African Amencan communities in the area surrounding Birmingham (in Jefferson County, Alabama);4) Develop a clinical trial infrastructure to provide CGMH patients with access to cancer clinical trials. Based on the demonstrated feasibility of IMPaCT, the effectiveness ofthe model in a hypothesis-driven research design will be evaluated. Building on the success of our Patient Navigator program for patients with abnormal breast mammograms and/or breast cancer, and on our experience with recruitment to cancer clinical trials, our innovative community-based program provides opportunities for African Americans diagnosed with cancer to participate in state-of-the-art cancer therapies. Increased participation of African Americans in clinical trials will contributes to the elimination of cancer health disparities.

Public Health Relevance

The UAB Cancer Outreach Program is directly relevant to the Partnership's goal of contributing to the elimination ofthe gap in cancer morbidity and mortality. The Patient Navigation Program creates an infrastructure for cancer clinical trials that enhances the participation of African Americans in therapeutic studies, thereby improving the translation of scientific discoveries to the African American community.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-Y (O1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Karthikeyan, Chandrabose; Lee, Crystal; Moore, Joshua et al. (2015) IND-2, a pyrimido[1?,2?:1,5]pyrazolo[3,4-b]quinoline derivative, circumvents multi-drug resistance and causes apoptosis in colon cancer cells. Bioorg Med Chem 23:602-11
Samuel, Temesgen; Fadlalla, Khalda; Gales, Dominique N et al. (2014) Variable NF-?B pathway responses in colon cancer cells treated with chemotherapeutic drugs. BMC Cancer 14:599
Wells, Kristen J; Lima, Diana S; Meade, Cathy D et al. (2014) Assessing needs and assets for building a regional network infrastructure to reduce cancer related health disparities. Eval Program Plann 44:14-25
Zhang, Huang-Ge; Grizzle, William E (2014) Exosomes: a novel pathway of local and distant intercellular communication that facilitates the growth and metastasis of neoplastic lesions. Am J Pathol 184:28-41
Richter, J R; Mahoney, M; Warram, J M et al. (2014) A dual-reporter, diagnostic vector for prostate cancer detection and tumor imaging. Gene Ther 21:897-902
Arora, Ritu; Yates, Clayton; Gary, Bernard D et al. (2014) Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer. PLoS One 9:e98370
Green, Hadiyah N; Crockett, Stephanie D; Martyshkin, Dmitry V et al. (2014) A histological evaluation and in vivo assessment of intratumoral near infrared photothermal nanotherapy-induced tumor regression. Int J Nanomedicine 9:5093-102
Khazal, Kamel F; Hill, Donald L; Grubbs, Clinton J (2014) Effect of Withania somnifera root extract on spontaneous estrogen receptor-negative mammary cancer in MMTV/Neu mice. Anticancer Res 34:6327-32
Jones, Jacqueline; Wang, Honghe; Karanam, Balasubramanyam et al. (2014) Nuclear localization of Kaiso promotes the poorly differentiated phenotype and EMT in infiltrating ductal carcinomas. Clin Exp Metastasis 31:497-510
Martin, Michelle Y; Fouad, Mona N; Oster, Robert A et al. (2014) What do cancer patients worry about when making decisions about treatment? Variation across racial/ethnic groups. Support Care Cancer 22:233-44

Showing the most recent 10 out of 55 publications