The UAB Cancer Outreach Program of the MSM/TU/UAB Partnership seeks to increase the accrual of African Americans into cancer clinical trials. Its goals are to 1) train Community Health Advisors (CHAs) as patient navigators to assist African American cancer patients overcome barriers to participation in cancer clinical trials;2) increase the recruitment and retention of African American cancer patients in therapeutic cancer clinical trials at UAB and Cooper Green Mercy Hospital (CGMH);3) develop and implement a culturally appropriate awareness of clinical trials and an educational program targeting African Amencan communities in the area surrounding Birmingham (in Jefferson County, Alabama);4) Develop a clinical trial infrastructure to provide CGMH patients with access to cancer clinical trials. Based on the demonstrated feasibility of IMPaCT, the effectiveness ofthe model in a hypothesis-driven research design will be evaluated. Building on the success of our Patient Navigator program for patients with abnormal breast mammograms and/or breast cancer, and on our experience with recruitment to cancer clinical trials, our innovative community-based program provides opportunities for African Americans diagnosed with cancer to participate in state-of-the-art cancer therapies. Increased participation of African Americans in clinical trials will contributes to the elimination of cancer health disparities.

Public Health Relevance

The UAB Cancer Outreach Program is directly relevant to the Partnership's goal of contributing to the elimination ofthe gap in cancer morbidity and mortality. The Patient Navigation Program creates an infrastructure for cancer clinical trials that enhances the participation of African Americans in therapeutic studies, thereby improving the translation of scientific discoveries to the African American community.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-Y (O1))
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University of Alabama Birmingham
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Tabatabai, Mohammad A; Kengwoung-Keumo, Jean-Jacques; Oates, Gabriela R et al. (2016) Racial and Gender Disparities in Incidence of Lung and Bronchus Cancer in the United States: A Longitudinal Analysis. PLoS One 11:e0162949
Akinyemiju, Tomi; Meng, Qingrui; Vin-Raviv, Neomi (2016) Association between body mass index and in-hospital outcomes: Analysis of the nationwide inpatient database. Medicine (Baltimore) 95:e4189
Wang, Honghe; Liu, Wei; Black, ShaNekkia et al. (2016) Kaiso, a transcriptional repressor, promotes cell migration and invasion of prostate cancer cells through regulation of miR-31 expression. Oncotarget 7:5677-89
Fouad, Mona N; Acemgil, Aras; Bae, Sejong et al. (2016) Patient Navigation As a Model to Increase Participation of African Americans in Cancer Clinical Trials. J Oncol Pract 12:556-63
Kamal, Arif H; Dionne-Odom, J Nicholas (2016) A Blue Ocean Strategy for Palliative Care: Focus on Family Caregivers. J Pain Symptom Manage 51:e1-3
Li, Rong; Zhang, Kui; Penedo, Thuy Linh et al. (2016) The RANK Pathway in Advanced Breast Cancer: Does Src Play a Role? Appl Immunohistochem Mol Morphol 24:42-50
Dionne-Odom, J Nicholas; Hull, Jay G; Martin, Michelle Y et al. (2016) Associations between advanced cancer patients' survival and family caregiver presence and burden. Cancer Med 5:853-62
Okwali, Michelle; Greenlee, Heather; Ginindza, Themba et al. (2016) Adherence to cancer prevention guidelines in South Africa is associated with health care access. Int Health 8:211-9
Costas, Laura; Lambert, Brice H; Birmann, Brenda M et al. (2016) A Pooled Analysis of Reproductive Factors, Exogenous Hormone Use, and Risk of Multiple Myeloma among Women in the International Multiple Myeloma Consortium. Cancer Epidemiol Biomarkers Prev 25:217-21
Jones, Jacqueline; Mukherjee, Angana; Karanam, Balasubramanyam et al. (2016) African Americans with pancreatic ductal adenocarcinoma exhibit gender differences in Kaiso expression. Cancer Lett 380:513-22

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