A key issue in evaluating the utility of nanomaterials is assessing their potential toxicity- either due to their inherent chemical composition (e.g. heavy metals) or as a consequence of their nanoscale properties (e.g. inhalation of particulate carbon nanotubes). The Toxicity Core (TC) proposed here will therefore provide the Harvard/MIT CCNE investigators the ability to rapidly characterize the potential toxicity of novel nanotechnology formulations using a panel of in vitro and in vivo assays. The Toxicity Core will be directed by Dr. Sangeeta Bhatia (MIT/BWH) in collaboration with the Mouse Model Core and consultants, Dr Jennifer Allport-Anderson (Novartis) and Dr. Monty Krieger (MIT). Models of basal and tissue-specific toxicity (endothelial, liver, and macrophage) will be available to test approximately 100 formulations per year in vitro, and a subset of these will be tested in mice with the input of veterinary pathologist, Dr. Rod Bronson. Promising formulations will be subsequently submitted to the NCL for full characterization through the formal application process or independently characterized by Charles River Laboratories.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA119349-05
Application #
7918223
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2009-09-01
Budget End
2010-08-31
Support Year
5
Fiscal Year
2009
Total Cost
$116,310
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
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