Significant advances in biotechnology and biochemistry have led to the discovery of a large number of cancer vaccines based on peptides and proteins. However, the development of suitable and efficient carrier systems remains a major challenge since the vaccine bioavailability is limited by enzymatic degradation. We developed recently several promising new vaccines for prostate cancer based on natural and modified survivin-derived peptides. We propose to encapsulate the survivin-derived peptide vaccines into our newly developed nanoparticles targeted to the mannose receptors on the dendritic cells. The inclusion of mannose or some of its derivatives in the nanoparticle formulation is expected to enhance delivery of active antigen and is the major conceptual advance of this pilot project. We suggest that this novel vaccine will induce potent and specific immune responses against prostate cancer. Because survivin is highly expressed in all prostate cancer, this new nanoparticle-vaccine strategy may have important clinical applications. This approach may provide a potential avenue for immunotherapy of prostate cancer, as many other prostate cancer-associated antigens have been described to date.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
3U54CA132384-05S2
Application #
8728360
Study Section
Special Emphasis Panel (ZCA1-SRRB-K (O1))
Program Officer
Aguila, H Nelson
Project Start
2008-09-29
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$1
Indirect Cost
$123,750
Name
San Diego State University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
073371346
City
San Diego
State
CA
Country
United States
Zip Code
92182
Gorman, Jessica R; Whitcomb, Brian W; Standridge, Daniel et al. (2016) Adoption consideration and concerns among young adult female cancer survivors. J Cancer Surviv :
Arevalo, Mariana; Jacobsen, Paul B; Gwede, Clement K et al. (2016) Development and validation of the biobanking attitudes and knowledge survey-Spanish (BANKS-SP). J Community Genet 7:303-314
Wells, Kristen J; Pan, Tonya M; Vázquez-Otero, Coralia et al. (2016) Barriers and facilitators to endocrine therapy adherence among underserved hormone-receptor-positive breast cancer survivors: a qualitative study. Support Care Cancer 24:4123-30
Kim, Jayeon; Mersereau, Jennifer E; Su, H Irene et al. (2016) Young female cancer survivors' use of fertility care after completing cancer treatment. Support Care Cancer 24:3191-9
Syme, Maggie L; Cohn, Tracy J (2016) Examining aging sexual stigma attitudes among adults by gender, age, and generational status. Aging Ment Health 20:36-45
Basa, Ranor C B; Davies, Vince; Li, Xiaoxiao et al. (2016) Decreased Anti-Tumor Cytotoxic Immunity among Microsatellite-Stable Colon Cancers from African Americans. PLoS One 11:e0156660
Champagne, Brian R; Fox, Rina S; Mills, Sarah D et al. (2016) Multidimensional profiles of health locus of control in Hispanic Americans. J Health Psychol 21:2376-85
Ustjanauskas, Amy E; Bredice, Marissa; Nuhaily, Sumayah et al. (2016) Training in Patient Navigation: A Review of the Research Literature. Health Promot Pract 17:373-81
Baik, Sharon H; Arevalo, Mariana; Gwede, Clement et al. (2016) Development and Validation of the Biomedical Research Trust Scale (BRTS) in English and Spanish. J Empir Res Hum Res Ethics :
Nuyen, Brian A; Fox, Rina S; Malcarne, Vanessa L et al. (2016) Excessive Daytime Sleepiness as an Indicator of Depression in Hispanic Americans. Hisp Health Care Int 14:116-23

Showing the most recent 10 out of 82 publications