Biostatistics Core A biostatistics core will be led by Dr. Feng Gao, Division of Biostatistics, Washington University School of Medicine. The role of biostatics core will be to lower the barriers to the incorporation of biostatistics to all levels of the translational research office, thereby ensuring that all of the NTR Center investigators will have access to high quality biostatistics input into their clinical and translational research projects from the start. Incorporating a biostatistical review early in study designs will ensure that the studies meet high standards of design and biostatistics. Increased support for methodological research will assure that appropriate methods will be developed to address the evolving challenges of rapidly changing translational research opportunities. Biostatistics Core of the Siteman Cancer Center frequently provides informatics services. These range from the manipulation and merging of existing electronic data sets to the creation of data entry systems. The Division of Biostatistics has considerable expertise in this area, particularly in its role as a coordinating center for diverse multi-institutional NIH-sponsored studies, or as a core for intramural centers and projects. The Division is a leader in the development of distributed data entry services. The current approach is a thin-client model with the use of a web browser on the client end and a web-server centrally. The standard programming environment for data management, statistical analysis and information delivery is SAS, and these web-based data entry systems are implemented with the SAS/lntrNet product. In order to support a wide variety of studies within the Siteman Cancer Center, the Core has collaborated with the Clinical Trials Core and with SAS Institute to create the Siteman Clinical Information Portal (SCIP). SCIP was created by customizing a previously-developed suite of browser-based form design tools. SCIP allows for the creation and management of data collection instruments by nonprogrammers and supports webbased data entry and editing.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRRB-9)
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Washington University
Saint Louis
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Hennen, Stella N; Xing, Wenxin; Shui, Ying-Bo et al. (2015) Photoacoustic tomography imaging and estimation of oxygen saturation of hemoglobin in ocular tissue of rabbits. Exp Eye Res 138:153-8
Garcia-Uribe, Alejandro; Erpelding, Todd N; Krumholz, Arie et al. (2015) Dual-Modality Photoacoustic and Ultrasound Imaging System for Noninvasive Sentinel Lymph Node Detection in Patients with Breast Cancer. Sci Rep 5:15748
Wang, Kezheng; Pan, Dipanjan; Schmieder, Anne H et al. (2015) Synergy between surface and core entrapped metals in a mixed manganese-gadolinium nanocolloid affords safer MR imaging of sparse biomarkers. Nanomedicine 11:601-9
Goette, Matthew J; Lanza, Gregory M; Caruthers, Shelton D et al. (2015) Improved quantitative (19) F MR molecular imaging with flip angle calibration and B1 -mapping compensation. J Magn Reson Imaging 42:488-94
Goette, Matthew J; Keupp, Jochen; Rahmer, J├╝rgen et al. (2015) Balanced UTE-SSFP for 19F MR imaging of complex spectra. Magn Reson Med 74:537-43
Stewart, Stephanie B; Koller, Jonathan M; Campbell, Meghan C et al. (2015) Additive global cerebral blood flow normalization in arterial spin labeling perfusion imaging. PeerJ 3:e834
Schmieder, Anne H; Caruthers, Shelton D; Keupp, Jochen et al. (2015) Recent Advances in (19)Fluorine Magnetic Resonance Imaging with Perfluorocarbon Emulsions. Engineering (Beijing) 1:475-489
Zhang, Ruiying; Pan, Dipanjan; Cai, Xin et al. (2015) alphaVbeta3-targeted copper nanoparticles incorporating an Sn 2 lipase-labile fumagillin prodrug for photoacoustic neovascular imaging and treatment. Theranostics 5:124-33
Wagner, Elizabeth M; Jenkins, John; Schmieder, Anne et al. (2015) Angiogenesis and airway reactivity in asthmatic Brown Norway rats. Angiogenesis 18:1-11
Tomlinson, Ryan E; Schmieder, Anne H; Quirk, James D et al. (2014) Antagonizing the ?v ?3 integrin inhibits angiogenesis and impairs woven but not lamellar bone formation induced by mechanical loading. J Bone Miner Res 29:1970-80

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