The recognition of cancer as a disease caused by the accumulation of genetic alterafions has motivated large-scale efforts to annotate the cancer genome for all human cancers. Mien combined with computafional approaches that can distinguish statistically significant, recurrent events from the background

Public Health Relevance

Greater knowledge ofthe temporal sequence of events during tumorigenesis is important to understand the mechanism(s) through which cancer genes cooperate, to promote the discovery of new biomarkers for early cancer detection, and to select which

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143798-04
Application #
8555275
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Project Start
2009-09-30
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
4
Fiscal Year
2012
Total Cost
$657,010
Indirect Cost
$104,331
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Wee, Boyoung; Pietras, Alexander; Ozawa, Tatsuya et al. (2016) ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells. Sci Rep 6:25956
Badri, H; Pitter, K; Holland, E C et al. (2016) Optimization of radiation dosing schedules for proneural glioblastoma. J Math Biol 72:1301-36
Amato, Katherine R; Wang, Shan; Tan, Li et al. (2016) EPHA2 Blockade Overcomes Acquired Resistance to EGFR Kinase Inhibitors in Lung Cancer. Cancer Res 76:305-18
Bolouri, Hamid; Zhao, Lue Ping; Holland, Eric C (2016) Big data visualization identifies the multidimensional molecular landscape of human gliomas. Proc Natl Acad Sci U S A 113:5394-9
Garvey, Colleen M; Spiller, Erin; Lindsay, Danika et al. (2016) A high-content image-based method for quantitatively studying context-dependent cell population dynamics. Sci Rep 6:29752
Xue, Qiong; Lu, Yao; Eisele, Markus R et al. (2015) Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation. Sci Signal 8:ra59
Kleppe, Maria; Kwak, Minsuk; Koppikar, Priya et al. (2015) JAK-STAT pathway activation in malignant and nonmalignant cells contributes to MPN pathogenesis and therapeutic response. Cancer Discov 5:316-31
Meador, Catherine B; Jin, Hailing; de Stanchina, Elisa et al. (2015) Optimizing the sequence of anti-EGFR-targeted therapy in EGFR-mutant lung cancer. Mol Cancer Ther 14:542-52
Foo, Jasmine; Liu, Lin L; Leder, Kevin et al. (2015) An Evolutionary Approach for Identifying Driver Mutations in Colorectal Cancer. PLoS Comput Biol 11:e1004350
Michor, Franziska; Beal, Kathryn (2015) Improving Cancer Treatment via Mathematical Modeling: Surmounting the Challenges Is Worth the Effort. Cell 163:1059-63

Showing the most recent 10 out of 154 publications