The PS-OC has organized a leadership structure to provide expertise and fully support all initiatives. The leadership consists of the Principal Investigator, Franziska Michor, PhD, and the Senior Co-investigator, Eric Holland, MD, PhD. Support personnel consists of the Administrator/Education Director, Desert Horse-Grant, Research/Project Manager, Raquel Sanchez, MBA, and Biostatistician, Mithat Gonen, PhD. The PS-OC leadership and support personnel, also known as the Administration, will work collectively to support and accomplish the proposed research projects, core, educational and training unit, outreach and dissemination unit, and pilot and trans-network projects. The PS-OC Steering Committee (PSC) will meet annually and will consist of two investigators from each PS-OC. The Principal Investigator, Dr. Franziska Michor, and the Senior Co-investigator, Dr. Holland, will represent our PS-OC at the PSC. The Center Advisory Committee (CAC) will bring together investigators with expertise in both the physical sciences and the basic sciences to form a group of voting and non-voting members. Specifically, the CAC will be made up of the following voting members: two physical sciences members, Franziska Michor (PD/PI), PhD, and Chris Sander, PhD;two biological/clinical members, William Pao, MD/PhD, and Eric Holland, MD/PhD;and an NCI appointed voting member. Non-voting members will include at least two external advisors with a wide spectrum of expertise, One external advisor will have a broad proficiency in signal transduction, cancer biology, program management and a focus on a tumor type unaffiliated with the projects of the PS-OC. At least one other external advisor will have advanced knowledge of one or more of the following: evolutionary theory, non-evolutionary cancer systems, developmental biology, brain cancer, lung cancer, leukemia, applied mathematics or engineering/microfabrication.

Public Health Relevance

The PS-OC has organized a leadership structure to provide expertise and fully support all initiatives. This structure is essential for the successful completion of the research projects proposed in the PS-OC.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143798-05
Application #
8566846
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$137,642
Indirect Cost
$21,619
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
Han, Lin; Zi, Xiaoyuan; Garmire, Lana X et al. (2014) Co-detection and sequencing of genes and transcripts from the same single cells facilitated by a microfluidics platform. Sci Rep 4:6485
Dunn, Gavin P; Cheung, Hiu Wing; Agarwalla, Pankaj K et al. (2014) In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proc Natl Acad Sci U S A 111:1102-7
Singh, Tanya; Kothapalli, Chandrasekhar; Varma, Devika et al. (2014) Carboxymethylcellulose hydrogels support central nervous system-derived tumor-cell chemotactic migration: comparison with conventional extracellular matrix macromolecules. J Biomater Appl 29:433-41
Meador, Catherine B; Micheel, Christine M; Levy, Mia A et al. (2014) Beyond histology: translating tumor genotypes into clinically effective targeted therapies. Clin Cancer Res 20:2264-75
Marusyk, Andriy; Tabassum, Doris P; Altrock, Philipp M et al. (2014) Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature 514:54-8
Foo, Jasmine; Michor, Franziska (2014) Evolution of acquired resistance to anti-cancer therapy. J Theor Biol 355:10-20
Tkach, Karen E; Oyler, Jennifer E; Altan-Bonnet, Grégoire (2014) Cracking the NF-?B code. Sci Signal 7:pe5
Guo, Shangqin; Zi, Xiaoyuan; Schulz, Vincent P et al. (2014) Nonstochastic reprogramming from a privileged somatic cell state. Cell 156:649-62
Leder, Kevin; Pitter, Ken; Laplant, Quincey et al. (2014) Mathematical modeling of PDGF-driven glioblastoma reveals optimized radiation dosing schedules. Cell 156:603-16
Elitas, Meltem; Brower, Kara; Lu, Yao et al. (2014) A microchip platform for interrogating tumor-macrophage paracrine signaling at the single-cell level. Lab Chip 14:3582-8

Showing the most recent 10 out of 95 publications