The proposed Center will make extensive use of a new Microfluidic Facility for the fabrication, assembly, and use of Microhabitat patches towards cancer and evolution experiments. A major goal for the proposed center is to facilitate the transfer of capabilities and knowledge from the physical sciences to biologists and medical researchers to learn more about cancer. Specifically, these capabilities are the "Microhabitat patches" (MHP) for studying the evolution of cancer cells under stress. These MHP's are microfluidic chips. Thus we are developing a staffed facility for biologists to make and to use microfluidic chips in general and microhabitat patches in particular for this proposed center. The facility consists of two functional pieces - one for making and packaging the microfluidic chips, and another for using the chips to do experiments (in this case biological with a cancer focus). Both of these functional pieces will be set up for remote operation and web interfaces, so that team members at institutions besides Princeton can make use of them. The facility will also be heavily used by the outreach and education/training sections of the center, and we expect by the pilot and transnetwork projects as well.
The proposed Center will make extensive use of a new Microfluidic Facility for the fabrication, assembly, and use of Microhabitat patches towards cancer and evolution experiments. The facility consists of two functional pieces - one for making and packaging the microfluidic chips, and another for using the chips to do experiments (in this case biological with a cancer focus).
|van Vliet, Simon; Hol, Felix J H; Weenink, Tim et al. (2014) The effects of chemical interactions and culture history on the colonization of structured habitats by competing bacterial populations. BMC Microbiol 14:116|
|Yang, Kimberline R; Mooney, Steven M; Zarif, Jelani C et al. (2014) Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem 115:1478-85|
|Wan, Liling; Hu, Guohong; Wei, Yong et al. (2014) Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 74:5336-47|
|DeFilippis, Rosa Anna; Fordyce, Colleen; Patten, Kelley et al. (2014) Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Res 74:5032-44|
|Lee, Mei-Chong Wendy; Lopez-Diaz, Fernando J; Khan, Shahid Yar et al. (2014) Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing. Proc Natl Acad Sci U S A 111:E4726-35|
|Terada, Naoki; Shiraishi, Takumi; Zeng, Yu et al. (2014) Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation. J Cell Biochem 115:1505-15|
|Chen, Duyu; Jiao, Yang; Torquato, Salvatore (2014) A cellular automaton model for tumor dormancy: emergence of a proliferative switch. PLoS One 9:e109934|
|Roca, Hernan; Pande, Manjusha; Huo, Jeffrey S et al. (2014) A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression. BMC Syst Biol 8:29|
|Fuhrmann, Alexander; Li, Julie; Chien, Shu et al. (2014) Cation type specific cell remodeling regulates attachment strength. PLoS One 9:e102424|
|Khin, Zayar P; Ribeiro, Maria L C; Jacobson, Timothy et al. (2014) A preclinical assay for chemosensitivity in multiple myeloma. Cancer Res 74:56-67|
Showing the most recent 10 out of 46 publications