Dissemination and outreach to both tell the world what our PSOC is doing and attract those from outside the center to work with us is a key part of our mission. The main goals of this section of our proposed PSOC are (i) Dissemination to the physical science/cancer biology communities of our PSOC capabilities and results (11) Strategies and mechanisms to bring expertise outside ofthe PSOC into collaboration with us, leading to pilot projects The outreach and dissemination will be initially focused on educating those outside our PSOC interested in working with us on the capabilities and power of microfludic microhabitat patches in particular, which are at the heart of our proposed work, and the interface of microfluidics and biology research in general. (The microhabitat patches and microfluidics are described technically in detail in N2/Project 4 and the N4 Microfluidic Shared Resource Facility). These in practice will serve as the focal point for where the physical science meets the cancer biology in our Center. We will educate researchers not just in the background and capabilities in this field, but use the Microfluidic facility at Princeton to give them hands on training so that they can use such chips by themselves. The facility will be set up so that remote collaborators can first design and have chips made remotely, and then so that they will be able to remotely run and control microfluidic experiments in the facility at Princeton. Extended outside visitor programs will also be available, with a goal of developing collaborations and a pilot project. Thus those outside our PSOC can learn in detail what our unique talents are, and then can then propose meaningful collaborations between their labs and the PSOC in the form of a pilot project, or even transnetwork projects.

Public Health Relevance

The main goals ofthis section of our proposed PSOC are (1) dissemination to the physical science/cancer biology communities of our PSOC capabilities and results, and (2) strategies and mechanisms to bring expertise outside ofthe PSOC into collaboration with us, leading to pilot projects.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-9)
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van Vliet, Simon; Hol, Felix J H; Weenink, Tim et al. (2014) The effects of chemical interactions and culture history on the colonization of structured habitats by competing bacterial populations. BMC Microbiol 14:116
Yang, Kimberline R; Mooney, Steven M; Zarif, Jelani C et al. (2014) Niche inheritance: a cooperative pathway to enhance cancer cell fitness through ecosystem engineering. J Cell Biochem 115:1478-85
Wan, Liling; Hu, Guohong; Wei, Yong et al. (2014) Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Res 74:5336-47
DeFilippis, Rosa Anna; Fordyce, Colleen; Patten, Kelley et al. (2014) Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density. Cancer Res 74:5032-44
Lee, Mei-Chong Wendy; Lopez-Diaz, Fernando J; Khan, Shahid Yar et al. (2014) Single-cell analyses of transcriptional heterogeneity during drug tolerance transition in cancer cells by RNA sequencing. Proc Natl Acad Sci U S A 111:E4726-35
Terada, Naoki; Shiraishi, Takumi; Zeng, Yu et al. (2014) Correlation of Sprouty1 and Jagged1 with aggressive prostate cancer cells with different sensitivities to androgen deprivation. J Cell Biochem 115:1505-15
Chen, Duyu; Jiao, Yang; Torquato, Salvatore (2014) A cellular automaton model for tumor dormancy: emergence of a proliferative switch. PLoS One 9:e109934
Roca, Hernan; Pande, Manjusha; Huo, Jeffrey S et al. (2014) A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression. BMC Syst Biol 8:29
Fuhrmann, Alexander; Li, Julie; Chien, Shu et al. (2014) Cation type specific cell remodeling regulates attachment strength. PLoS One 9:e102424
Khin, Zayar P; Ribeiro, Maria L C; Jacobson, Timothy et al. (2014) A preclinical assay for chemosensitivity in multiple myeloma. Cancer Res 74:56-67

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