Dissemination and outreach to both tell the world what our PSOC is doing and attract those from outside the center to work with us is a key part of our mission. The main goals of this section of our proposed PSOC are (i) Dissemination to the physical science/cancer biology communities of our PSOC capabilities and results (11) Strategies and mechanisms to bring expertise outside ofthe PSOC into collaboration with us, leading to pilot projects The outreach and dissemination will be initially focused on educating those outside our PSOC interested in working with us on the capabilities and power of microfludic microhabitat patches in particular, which are at the heart of our proposed work, and the interface of microfluidics and biology research in general. (The microhabitat patches and microfluidics are described technically in detail in N2/Project 4 and the N4 Microfluidic Shared Resource Facility). These in practice will serve as the focal point for where the physical science meets the cancer biology in our Center. We will educate researchers not just in the background and capabilities in this field, but use the Microfluidic facility at Princeton to give them hands on training so that they can use such chips by themselves. The facility will be set up so that remote collaborators can first design and have chips made remotely, and then so that they will be able to remotely run and control microfluidic experiments in the facility at Princeton. Extended outside visitor programs will also be available, with a goal of developing collaborations and a pilot project. Thus those outside our PSOC can learn in detail what our unique talents are, and then can then propose meaningful collaborations between their labs and the PSOC in the form of a pilot project, or even transnetwork projects.

Public Health Relevance

The main goals ofthis section of our proposed PSOC are (1) dissemination to the physical science/cancer biology communities of our PSOC capabilities and results, and (2) strategies and mechanisms to bring expertise outside ofthe PSOC into collaboration with us, leading to pilot projects.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143803-05
Application #
8535655
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$88,302
Indirect Cost
Name
Princeton University
Department
Type
DUNS #
002484665
City
Princeton
State
NJ
Country
United States
Zip Code
08544
Chalfin, Heather J; Glavaris, Stephanie A; Malihi, Paymaneh D et al. (2018) Prostate Cancer Disseminated Tumor Cells are Rarely Detected in the Bone Marrow of Patients with Localized Disease Undergoing Radical Prostatectomy across Multiple Rare Cell Detection Platforms. J Urol 199:1494-1501
Chalfin, Heather J; Kates, Max; van der Toom, Emma E et al. (2018) Characterization of Urothelial Cancer Circulating Tumor Cells with a Novel Selection-Free Method. Urology 115:82-86
de Groot, Amber E; Pienta, Kenneth J (2018) Epigenetic control of macrophage polarization: implications for targeting tumor-associated macrophages. Oncotarget 9:20908-20927
Wu, Amy; Liao, David; Kirilin, Vlamimir et al. (2018) Cancer dormancy and criticality from a game theory perspective. Cancer Converg 2:1
van der Toom, Emma E; Axelrod, Haley D; de la Rosette, Jean J et al. (2018) Prostate-specific markers to identify rare prostate cancer cells in liquid biopsies. Nat Rev Urol :
Valkenburg, Kenneth C; de Groot, Amber E; Pienta, Kenneth J (2018) Targeting the tumour stroma to improve cancer therapy. Nat Rev Clin Oncol 15:366-381
Maley, Carlo C; Aktipis, Athena; Graham, Trevor A et al. (2017) Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer 17:605-619
Piotrowski-Daspit, Alexandra S; Simi, Allison K; Pang, Mei-Fong et al. (2017) A 3D Culture Model to Study How Fluid Pressure and Flow Affect the Behavior of Aggregates of Epithelial Cells. Methods Mol Biol 1501:245-257
Parsana, Princy; Amend, Sarah R; Hernandez, James et al. (2017) Identifying global expression patterns and key regulators in epithelial to mesenchymal transition through multi-study integration. BMC Cancer 17:447
Decker, A M; Cackowski, F C; Jung, Y et al. (2017) Biochemical Changes in the Niche Following Tumor Cell Invasion. J Cell Biochem 118:1956-1964

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