The Principal Investigator of the proposed CTO is Dr. Mauro Ferrari, Chairman of Biomedical Engineering, Director of the Division of Nanomedicine, and Professor of Internal Medicine at UTHSC-H. Dr. Ferrari holds concurrent faculty appointments at MDACC, Rice U and UTA, and is the President of the Alliance for NanoHealth. He is trained in mathematics, mechanical engineering and medicine. He is a recognized leader in the development and application of biomedical nanotechnology. Co-leading the CTO is Senior Colnvestigator, Dr. Steven Curiey of MDACC, Professor and Chief, Gastrointestinal Tumor Surgery, Program Director, Gastrointestinal Tumor Multidisciplinary Care Center and the Charles B. Barker Chair in Surgery. He is a renowned Gl tumor surgeon and physician scientist. Drs. Ferrari and Curiey will lead the proposed CTO from the physical sciences and clinical and oncology sciences, respectively. Both have demonstrated experience to conduct and lead multidisciplinary research programs that bridge the physical sciences and biomedical and clinical sciences. CTO Center Administrative Unit, led by the PI and Senior Co-lnvestigator will be assisted by a Center Manager, Dr. Jason Sakamoto, to provide leadership and general administration for all activities related to this proposed CTO. Dr. Apostolia Tsimberidou, Assitant Professor at MDACC, will be Director of Clinical Translation, Education and Outreach. She will guide and advise the investigators in their research toward clinical translation. CTO Center Administrative Unit is responsible for: 1) providing administrative support to all projects and core resources of the CTO, 2) providing administrative support to develop and manage pilot project programs (Internal pilot projects-CAC, TransNetwork pilot projects-PSC, and external pilot projects-outreach), 3) convening CTO team meetings, CAC meetings, as well as scientific conferences and workshops, 4) supporting the participation of the CTO in PS-OC network and communicate with NCI staff, facilitate and prepare the CTO participation in NCI evaluation, 5) facilitating communication with other PS-OCs, and among other administrative and supportive functions, and 6) interfacing with other administrative resources and shared core facilities in the participating institutions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143837-06
Application #
8564195
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Project Start
2009-09-28
Project End
2015-07-31
Budget Start
2013-09-19
Budget End
2014-07-31
Support Year
Fiscal Year
2013
Total Cost
$147,972
Indirect Cost
$51,886
Name
Methodist Hospital Research Institute
Department
Type
DUNS #
185641052
City
Houston
State
TX
Country
United States
Zip Code
77030
Pandolfi, Laura; Minardi, Silvia; Taraballi, Francesca et al. (2016) Composite microsphere-functionalized scaffold for the controlled release of small molecules in tissue engineering. J Tissue Eng 7:2041731415624668
Ware, Matthew J; Keshishian, Vazrik; Law, Justin J et al. (2016) Generation of an in vitro 3D PDAC stroma rich spheroid model. Biomaterials 108:129-42
Lapin, Norman A; Krzykawska-Serda, Martyna; Ware, Matthew J et al. (2016) Intravital microscopy for evaluating tumor perfusion of nanoparticles exposed to non-invasive radiofrequency electric fields. Cancer Nanotechnol 7:5
Tanei, Tomonori; Leonard, Fransisca; Liu, Xuewu et al. (2016) Redirecting Transport of Nanoparticle Albumin-Bound Paclitaxel to Macrophages Enhances Therapeutic Efficacy against Liver Metastases. Cancer Res 76:429-39
McConnell, Kellie I; Shamsudeen, Sabeel; Meraz, Ismail M et al. (2016) Reduced Cationic Nanoparticle Cytotoxicity Based on Serum Masking of Surface Potential. J Biomed Nanotechnol 12:154-64
Scott, Bronwyn; Shen, Jianliang; Nizzero, Sara et al. (2016) A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells. Pharmacol Res 111:413-21
Mi, Yu; Mu, Chaofeng; Wolfram, Joy et al. (2016) A Micro/Nano Composite for Combination Treatment of Melanoma Lung Metastasis. Adv Healthc Mater 5:936-46
Corbo, Claudia; Molinaro, Roberto; Parodi, Alessandro et al. (2016) The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery. Nanomedicine (Lond) 11:81-100
Liu, Zongbin; Han, Xin; Qin, Lidong (2016) Recent Progress of Microfluidics in Translational Applications. Adv Healthc Mater 5:871-88
Leonard, Fransisca; Godin, Biana (2016) 3D In Vitro Model for Breast Cancer Research Using Magnetic Levitation and Bioprinting Method. Methods Mol Biol 1406:239-51

Showing the most recent 10 out of 226 publications