Core 1 is the conceptual driver for the entire Center. It is founded on the conviction that the physical sciences in general, and physics in particular, offer new and penetrating insights into the origin, behavior and management of cancer. By asking disruptive, provocative and challenging questions, the Core will facilitate the sort of major conceptual leap that will transform understanding ofthe subject. Core 1 will exploit the highly successful """"""""brainstorming"""""""" ethos ofthe Beyond Center for Fundamental Concepts in Science at Arizona State University, a """"""""think

Public Health Relevance

Progress in cancer has been incremental, but slow. Our Center seeks to create a new paradigm based on the physical correlates of cancer cell progression. Its education and outreach components, to be managed by Core 1, targets sections ofthe community with special vulnerabilities to cancer, as well as training a new cadre of scientists working at the interface of physics and cancer cell biology.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143862-05
Application #
8744854
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Project Start
2013-09-01
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$556,558
Indirect Cost
$143,130
Name
Arizona State University-Tempe Campus
Department
Type
DUNS #
943360412
City
Tempe
State
AZ
Country
United States
Zip Code
85287
Bosch, Linda J W; Luo, Yanxin; Lao, Victoria V et al. (2016) WRN Promoter CpG Island Hypermethylation Does Not Predict More Favorable Outcomes for Patients with Metastatic Colorectal Cancer Treated with Irinotecan-Based Therapy. Clin Cancer Res 22:4612-22
Cohen, Stacey A; Wu, Chen; Yu, Ming et al. (2016) Evaluation of CpG Island Methylator Phenotype as a Biomarker in Colorectal Cancer Treated With Adjuvant Oxaliplatin. Clin Colorectal Cancer 15:164-9
Nandakumar, Vivek; Hansen, Nanna; Glenn, Honor L et al. (2016) Vorinostat differentially alters 3D nuclear structure of cancer and non-cancerous esophageal cells. Sci Rep 6:30593
Staunton, Jack R; Doss, Bryant L; Lindsay, Stuart et al. (2016) Correlating confocal microscopy and atomic force indentation reveals metastatic cancer cells stiffen during invasion into collagen I matrices. Sci Rep 6:19686
Senapati, Subhadip; Lindsay, Stuart (2016) Recent Progress in Molecular Recognition Imaging Using Atomic Force Microscopy. Acc Chem Res 49:503-10
Okugawa, Yoshinaga; Grady, William M; Goel, Ajay (2015) Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers. Gastroenterology 149:1204-1225.e12
Manna, Saikat; Senapati, Subhadip; Lindsay, Stuart et al. (2015) A three-arm scaffold carrying affinity molecules for multiplex recognition imaging by atomic force microscopy: the synthesis, attachment to silicon tips, and detection of proteins. J Am Chem Soc 137:7415-23
Shiovitz, Stacey; Grady, William M (2015) Molecular markers predictive of chemotherapy response in colorectal cancer. Curr Gastroenterol Rep 17:431
Wu, Amy; Zhang, Qiucen; Lambert, Guillaume et al. (2015) Ancient hot and cold genes and chemotherapy resistance emergence. Proc Natl Acad Sci U S A 112:10467-72
Kaz, Andrew M; Grady, William M; Stachler, Matthew D et al. (2015) Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterol Clin North Am 44:473-89

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