The Materials Core (Biological Sample and Processing) is comprised ofthe Fred Hutchinson Cancer Research Center (FHCRC) and the Mayo Clinic Scottsdale. The two entities will be responsible for providing cell line and tissue reagents in support of all projects within the Center and will support the development of common reagents. Each project research plan requires well-characterized cell lines and primary tissues to further the experimental goals ofthe Center. The FHCRC portion ofthe Core will be under the direction of Dr. William Grady, who will manage the cell lines used in projects 1 through 3. The Mayo Clinic portion ofthe Core will be under the direction of Dr. Joseph Mikhaels, who will coordinate the collection and characterization of tissues. The cell lines that will be maintained and distributed to researchers are colon adenoma and adenocarcinoma and Barrett's Esophagus and esophageal adenocarcinoma cell lines. Primary tissue samples will be collected during endoscopy and colonoscopy following procedures approved by the Institutional Review Board at Mayo Clinic.

Public Health Relevance

This Core will provide experimental samples for all experiments designed and completed within the other projects of the Center. The projects will contribute to the overall understanding of cancer, which would not be possible without this Core. By providing samples of cancer for experimentation, the Core is directly and positively impacting progress made in cancer research.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143862-05
Application #
8744855
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Project Start
2013-09-01
Project End
2014-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
5
Fiscal Year
2013
Total Cost
$101,894
Indirect Cost
$26,204
Name
Arizona State University-Tempe Campus
Department
Type
DUNS #
943360412
City
Tempe
State
AZ
Country
United States
Zip Code
85287
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Manna, Saikat; Senapati, Subhadip; Lindsay, Stuart et al. (2015) A three-arm scaffold carrying affinity molecules for multiplex recognition imaging by atomic force microscopy: the synthesis, attachment to silicon tips, and detection of proteins. J Am Chem Soc 137:7415-23
Shiovitz, Stacey; Grady, William M (2015) Molecular markers predictive of chemotherapy response in colorectal cancer. Curr Gastroenterol Rep 17:431
Wu, Amy; Zhang, Qiucen; Lambert, Guillaume et al. (2015) Ancient hot and cold genes and chemotherapy resistance emergence. Proc Natl Acad Sci U S A 112:10467-72
Kaz, Andrew M; Grady, William M; Stachler, Matthew D et al. (2015) Genetic and Epigenetic Alterations in Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterol Clin North Am 44:473-89

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