The interface between the physical sciences and medicine is a new frontier for scientific exploration and, ultimately, for the creation of new and improved diagnostic and therapeutic tools to detect, treat, cure, and prevent human diseases. As an integral part of the Center for Cancer Physics, we propose to create a combined predoctoral and postdoctoral training program in physics of cancer that will be positioned at this interface and will establish a unique national resource with interdisciplinary and synergistic programs in fundamental research in cancer biology. This program will train predoctoral students and postdoctoral fellows across disciplines to lay foundations of cancer physics that will enable a new view of cancer cell function grounded in the physical sciences. The program will train a cadre of students and fellows for careers in research in academia by emphasizing eariy independence in research. Students and fellows will take advantage of research and clinical resources at the Johns Hopkins Hospital, including the NCI-designated Sidney Kimmel Comprehensive Cancer Center, the Ludwig Institute for Cancer Genetics and Therapeutics, the Sol Goldman Pancreatic Cancer Center, the In Vivo Cellular and Molecular Imaging Center, the unique educational resources and experimental facilities of the Johns Hopkins Institute for NanoBioTechnology (INBT website:, as well as the Washington University Medical School's NCI-designated Siteman Comprehensive Cancer Center, The Cancer Biology Program, the Siteman Center of Cancer Nanotechnology Excellence, and the Molecular Imaging Center, and at the University of North Carolina Medical School's NIH funded Curriculum in Bioinformatics and Computational Biology and NIH-funded Molecular and Cellular Biophysics Graduate Training Program.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-9)
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Johns Hopkins University
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Kim, Jeong-Ki; Louhghalam, Arghavan; Lee, Geonhui et al. (2017) Nuclear lamin A/C harnesses the perinuclear apical actin cables to protect nuclear morphology. Nat Commun 8:2123
Ju, Julia A; Godet, InĂªs; Ye, I Chae et al. (2017) Hypoxia Selectively Enhances Integrin ?5?1 Receptor Expression in Breast Cancer to Promote Metastasis. Mol Cancer Res 15:723-734
Ruhland, Megan K; Loza, Andrew J; Capietto, Aude-Helene et al. (2016) Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nat Commun 7:11762
Lan, Tian; Cheng, Kai; Ren, Tina et al. (2016) Displacement correlations between a single mesenchymal-like cell and its nucleus effectively link subcellular activities and motility in cell migration analysis. Sci Rep 6:34047
Lee, Pilhwa; Wolgemuth, Charles W (2016) Physical Mechanisms of Cancer in the Transition to Metastasis. Biophys J 111:256-66
Semenza, Gregg L (2016) The hypoxic tumor microenvironment: A driving force for breast cancer progression. Biochim Biophys Acta 1863:382-391
Zhang, Kun; Grither, Whitney R; Van Hove, Samantha et al. (2016) Mechanical signals regulate and activate SNAIL1 protein to control the fibrogenic response of cancer-associated fibroblasts. J Cell Sci 129:1989-2002
He, Lijuan; Chen, Weitong; Wu, Pei-Hsun et al. (2016) Local 3D matrix confinement determines division axis through cell shape. Oncotarget 7:6994-7011
Sarnecki, Jacob S; Burns, Kathleen H; Wood, Laura D et al. (2016) A robust nonlinear tissue-component discrimination method for computational pathology. Lab Invest 96:450-8
Semenza, Gregg L (2016) Novel strategies for cancer therapy. J Mol Med (Berl) 94:119-20

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