Trans-Network Projects One potent mediator for setting up for collaborations between PS-OCs will be technology transfer. In addition to our work with the PS-OC Steering Committee on identifying trans-network projects, the SCDC PS-OC will develop novel technology platforms that will be generally applicable to many experimental systems in cancer biology. In particular the RNA counting technique mastered by the van Oudenaarden lab and the suspended microchannel resonant (SMR) mass sensor developed by the Manalis lab will likely be useful technologies for other PS-OCs. Below we outiine concrete strategies that we will pursue to establish successful and longlasting collaborations with other PS-OCs within the network.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143874-05
Application #
8535665
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
5
Fiscal Year
2013
Total Cost
$92,893
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
McFarland, Christopher D (2016) A modified ziggurat algorithm for generating exponentially- and normally-distributed pseudorandom numbers. J Stat Comput Simul 86:1281-1294
Cermak, Nathan; Olcum, Selim; Delgado, Francisco Feijó et al. (2016) High-throughput measurement of single-cell growth rates using serial microfluidic mass sensor arrays. Nat Biotechnol 34:1052-1059
Hosios, Aaron M; Hecht, Vivian C; Danai, Laura V et al. (2016) Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells. Dev Cell 36:540-9
Stevens, Mark M; Maire, Cecile L; Chou, Nigel et al. (2016) Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat Biotechnol 34:1161-1167
Kimmerling, Robert J; Lee Szeto, Gregory; Li, Jennifer W et al. (2016) A microfluidic platform enabling single-cell RNA-seq of multigenerational lineages. Nat Commun 7:10220
Hecht, Vivian C; Sullivan, Lucas B; Kimmerling, Robert J et al. (2016) Biophysical changes reduce energetic demand in growth factor-deprived lymphocytes. J Cell Biol 212:439-47
Akutagawa, J; Huang, T Q; Epstein, I et al. (2016) Targeting the PI3K/Akt pathway in murine MDS/MPN driven by hyperactive Ras. Leukemia 30:1335-43
Shaw Bagnall, Josephine; Byun, Sangwon; Miyamoto, David T et al. (2016) Deformability-based cell selection with downstream immunofluorescence analysis. Integr Biol (Camb) 8:654-64
Ramanan, Vyas; Trehan, Kartik; Ong, Mei-Lyn et al. (2016) Viral genome imaging of hepatitis C virus to probe heterogeneous viral infection and responses to antiviral therapies. Virology 494:236-47
Shaw Bagnall, Josephine; Byun, Sangwon; Begum, Shahinoor et al. (2015) Deformability of Tumor Cells versus Blood Cells. Sci Rep 5:18542

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