The Center on the Microenvironment and Metastasis will be operated as a Multi-Institutional Interdisciplinary ResearchCenter managed by Cornell University using established mechanisms and an experienced financial, administration andtechnical support staff. Our PS-OC organization will incorporate successful process management proceduresdeveloped at Cornell. Existing administrative structures and resources, shared research faciiities and underlyingtechnological capabilities will be utilized for this new PS-OC enterprise targeted toward cancer research,Cornell University will be the lead institution of our Center on the Microenvironment and Metastasis. The university hasa strong tradition of multi-institutional research organizations and PS-OC faculty and staff will build on this to establish aPS-OC organization that will quickly and effectively support and enhance the research projects of the Center. OurCenter will include leaders in the fields of physics, nanobiotechnology, nanotechnology and biomedical engineering atCornell. Leaders in cancer biology research from V/eill Cornell Medical College in New York City will play a critical rolein our Center, as will colleagues at the State University of New Yorkat Buffalo.The Center Advisory Committee will assess overall progress in research, education, and implementation, andpartnership development. This assessment will be set in the context of each committee member's area of expertise, asthese members collectively will represent the core areas of the center. Key recommendations for future development ofthe Center will be decided upon by this group, and reports from their meetings will be shared with the Center Directorand the Executive CommitteeWe recognize the important role the Physical Sciences-Oncology Centers Steering Committee (PSC) will play in thesuccess of the PS-OC network. Our Center will be represented on this committee by Harold Craighead (Pi/Director) andBarbara Hempstead (senior co-investigator/Co-Director). Our PS-OC representatives on this committee will bringdetailed knowledge of progress in our Center's research projects that will enable them to propose and promotecollaborations with colleagues at other PS-OCs through trans-Network projects.
This PS-OC brings together expert teams from the fields of physics, nano and microfabrication, engineering and cancer biology to develop novel trans-disciplinary approaches to better understand the complexity of cancer metastasis, the aspect of cancer that directly leads to patient morbidity and mortality. Approaches developed by physical scientists will be focused on the study of cancer. Our studies aim to identify novel mechanisms used by cancer cells, but not normal cells, for growth and metastasis to distant body sites. These new mechanism provide novel drug targets, that aim towards arresting cancer metastasis.
|Cao, Xuan; Moeendarbary, Emad; Isermann, Philipp et al. (2016) A Chemomechanical Model for Nuclear Morphology and Stresses during Cell Transendothelial Migration. Biophys J 111:1541-1552|
|McCoy, Michael G; Seo, Bo Ri; Choi, Siyoung et al. (2016) Collagen I hydrogel microstructure and composition conjointly regulate vascular network formation. Acta Biomater 44:200-8|
|Denais, Celine M; Gilbert, Rachel M; Isermann, Philipp et al. (2016) Nuclear envelope rupture and repair during cancer cell migration. Science 352:353-8|
|Duncan, Sara M; Seigel, Gail M (2016) High-contrast enzymatic immunohistochemistry of pigmented tissues. J Biol Methods 3:|
|Seigel, G M; Sharma, S; Hackam, A S et al. (2016) HER2/ERBB2 immunoreactivity in human retinoblastoma. Tumour Biol 37:6135-42|
|Chandrasekaran, Siddarth; Chan, Maxine F; Li, Jiahe et al. (2016) Super natural killer cells that target metastases in the tumor draining lymph nodes. Biomaterials 77:66-76|
|Wang, Suming; Blois, Anna; El Rayes, Tina et al. (2016) Development of a prosaposin-derived therapeutic cyclic peptide that targets ovarian cancer via the tumor microenvironment. Sci Transl Med 8:329ra34|
|Hall, Matthew S; Alisafaei, Farid; Ban, Ehsan et al. (2016) Fibrous nonlinear elasticity enables positive mechanical feedback between cells and ECMs. Proc Natl Acad Sci U S A 113:14043-14048|
|Bordeleau, Francois; Chan, Bryan; Antonyak, Marc A et al. (2016) Microvesicles released from tumor cells disrupt epithelial cell morphology and contractility. J Biomech 49:1272-9|
|Levin, Michael; Klar, Amar J S; Ramsdell, Ann F (2016) Introduction to provocative questions in left-right asymmetry. Philos Trans R Soc Lond B Biol Sci 371:|
Showing the most recent 10 out of 183 publications