The overall goal of the Dynomics Project is to provide a molecular genomic 'fingerprint'ofthe genome and transcriptome of cancer cells at all stages of development that can serve as a platform for identify patterns or relationships between physical, morphological, and genomic parameters and correlate those properties with the stage or evolution of the disease in a patient. The samples that we will utilize will match those used in RP1 and RP2 such that the

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The genomic and transcriptomic data set to be generated across space in tumor tissue and in time from circulating tumor cells will provide a dynamic parameterization of two distinct forms of cancer, colon and lung. The integration of these data sets into a physical modeling framework will provide unique insights into the physical dynamics of cancer progression.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-9)
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Scripps Research Institute
La Jolla
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Phillips, Kevin G; Kuhn, Peter; McCarty, Owen J T (2014) Physical biology in cancer. 2. The physical biology of circulating tumor cells. Am J Physiol Cell Physiol 306:C80-8
Jones, Casey M; Baker-Groberg, Sandra M; Cianchetti, Flor A et al. (2014) Measurement science in the circulatory system. Cell Mol Bioeng 7:1-14
Dago, Angel E; Stepansky, Asya; Carlsson, Anders et al. (2014) Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. PLoS One 9:e101777
Phillips, Kevin G; Baker-Groberg, Sandra M; McCarty, Owen J T (2014) Quantitative optical microscopy: measurement of cellular biophysical features with a standard optical microscope. J Vis Exp :
Rodriguez-Lee, Mariam; Kuhn, Peter; Webb, David R (2014) Advancing cancer patient care by integrating circulating tumor cell technology to understand the spatial and temporal dynamics of cancer. Drug Dev Res 75:384-92
Totonchy, Jennifer E; Clepper, Lisa; Phillips, Kevin G et al. (2014) CXCR7 expression disrupts endothelial cell homeostasis and causes ligand-dependent invasion. Cell Adh Migr 8:165-76
Carlsson, Anders; Nair, Viswam S; Luttgen, Madelyn S et al. (2014) Circulating tumor microemboli diagnostics for patients with non-small-cell lung cancer. J Thorac Oncol 9:1111-9
Bethel, Kelly; Luttgen, Madelyn S; Damani, Samir et al. (2014) Fluid phase biopsy for detection and characterization of circulating endothelial cells in myocardial infarction. Phys Biol 11:016002
Bazhenova, Lyudmila; Newton, Paul; Mason, Jeremy et al. (2014) Adrenal metastases in lung cancer: clinical implications of a mathematical model. J Thorac Oncol 9:442-6
Baker-Groberg, Sandra M; Phillips, Kevin G; McCarty, Owen J T (2013) Quantification of volume, mass, and density of thrombus formation using brightfield and differential interference contrast microscopy. J Biomed Opt 18:16014

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