The Administrative Core (AC) will function to manage the CAC and help administer and support the PSOCMC- SMART. The will help coordinate the CAC twice monthly meetings. The CAC, together with the program manager, will assure that project and core plans progress, postdoctoral fellows are shared, training and outreach efforts are implemented, pilot projects are encouraged and funded, and the 'business'of the program is accomplished. A key element of the AC will be a full time program manager who will work closely with Drs. Hillis as well the other members of the Center Advisory Committee to help execute all recommendations of the CAC, NCI Project Scientist and the PSC. The AC will assure that all meeting generated notes/reports to the CAC and PSC are prepared and disseminated. Additionally, as both integrative education and community outreach are such significant portions of the PSOC-MC-START program, the AC will be managing the PSOC-MC-SMART website and the implementation of the PSOC-MCSTART member ectures/seminars in both the i) newly planned series, and the ii) leveraged series at our collaborating institutions, and professional association meetings, to educate about physical sciences and oncology.

Public Health Relevance

Clinical tools to accurately describe, evaluate and predict an individual's response to cancer therapy are a field-wide priority. Through our virtual cancer, we anticipate it will become possible to take a small number of measurements from a patient, input those measurements as calibrants to our virtual cancer and then simulate the growth and response to therapy of the patient.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143907-03
Application #
8145269
Study Section
Special Emphasis Panel (ZCA1-SRLB-9 (O1))
Program Officer
Hanlon, Sean E
Project Start
2009-09-28
Project End
2014-07-31
Budget Start
2011-08-01
Budget End
2012-07-31
Support Year
3
Fiscal Year
2011
Total Cost
$3,039,587
Indirect Cost
Name
University of Southern California
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Garvey, Colleen M; Gerhart, Torin A; Mumenthaler, Shannon M (2017) Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques. J Vis Exp :
Tennill, Thomas A; Gross, Mitchell E; Frieboes, Hermann B (2017) Automated analysis of co-localized protein expression in histologic sections of prostate cancer. PLoS One 12:e0178362
Yan, Huaming; Romero-López, Mónica; Benitez, Lesly I et al. (2017) 3D Mathematical Modeling of Glioblastoma Suggests That Transdifferentiated Vascular Endothelial Cells Mediate Resistance to Current Standard-of-Care Therapy. Cancer Res 77:4171-4184
Ng, Chin F; Frieboes, Hermann B (2017) Model of vascular desmoplastic multispecies tumor growth. J Theor Biol 430:245-282
Leonard, Fransisca; Curtis, Louis T; Yesantharao, Pooja et al. (2016) Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions. Nanoscale 8:12544-52
Baugh, Evan H; Simmons-Edler, Riley; Müller, Christian L et al. (2016) Robust classification of protein variation using structural modelling and large-scale data integration. Nucleic Acids Res 44:2501-13
Ghaffarizadeh, Ahmadreza; Friedman, Samuel H; Macklin, Paul (2016) BioFVM: an efficient, parallelized diffusive transport solver for 3-D biological simulations. Bioinformatics 32:1256-8
Juarez, Edwin F; Lau, Roy; Friedman, Samuel H et al. (2016) Quantifying differences in cell line population dynamics using CellPD. BMC Syst Biol 10:92
Park, Seung-Min; Lee, Jae Young; Hong, Soongweon et al. (2016) Dual transcript and protein quantification in a massive single cell array. Lab Chip 16:3682-8

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