Abstract

Trans-Network Projects We are excited to establish Trans-Network collaborative pilot projects with other PS-OCs as they are identified and/or come online. We have already established contacts (based on previous and ongoing discussions and collaboration with Dr. Steve Quake) with the STANFORD'S PS-OC, a center based around cancer stem cells. There are obvious synergies between the two centers, as we will create and analyze tumors formed from individually activated founder cells. We have agreed to help them implement the single cell activation/uncaging technology. They have in turn agreed to help us build-up and establish our core 3 and implement their various microfiuidic single cell-based assays, which will be essential for the spatio-temporal analysis and evolution of a growing tumor. We have on-going collaborations also with the Weiss UCLA PS-OC studying signaling pathway activation and Dr. Peter Kuhn of Scripps around circulating tumor cells. We have additional relationships with MIT, and Dr. Scott Manalis, in particular, around single-cell sensors.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Specialized Center--Cooperative Agreements (U54)
Project #
5U54CA143907-04
Application #
8381745
Study Section
Special Emphasis Panel (ZCA1-SRLB-9)
Project Start
Project End
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
4
Fiscal Year
2012
Total Cost
$98,939
Indirect Cost

  Institution

Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089

  Publications

Ng, Chin F; Frieboes, Hermann B (2018) Simulation of Multispecies Desmoplastic Cancer Growth via a Fully Adaptive Non-linear Full Multigrid Algorithm. Front Physiol 9:821
Tipton, Laura; Müller, Christian L; Kurtz, Zachary D et al. (2018) Fungi stabilize connectivity in the lung and skin microbial ecosystems. Microbiome 6:12
Lee, Jung-Rok; Appelmann, Iris; Miething, Cornelius et al. (2018) Longitudinal Multiplexed Measurement of Quantitative Proteomic Signatures in Mouse Lymphoma Models Using Magneto-Nanosensors. Theranostics 8:1389-1398
Lee, Jung-Rok; Chan, Carmel T; Ruderman, Daniel et al. (2017) Longitudinal Monitoring of Antibody Responses against Tumor Cells Using Magneto-nanosensors with a Nanoliter of Blood. Nano Lett 17:6644-6652
Yan, Huaming; Romero-Lopez, Monica; Frieboes, Hermann B et al. (2017) Multiscale Modeling of Glioblastoma Suggests that the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk Can Promote Tumor Regression Without Increasing Invasiveness. IEEE Trans Biomed Eng 64:538-548
Yan, Huaming; Romero-López, Mónica; Benitez, Lesly I et al. (2017) 3D Mathematical Modeling of Glioblastoma Suggests That Transdifferentiated Vascular Endothelial Cells Mediate Resistance to Current Standard-of-Care Therapy. Cancer Res 77:4171-4184
Tennill, Thomas A; Gross, Mitchell E; Frieboes, Hermann B (2017) Automated analysis of co-localized protein expression in histologic sections of prostate cancer. PLoS One 12:e0178362
Ware, Matthew J; Curtis, Louis T; Wu, Min et al. (2017) Pancreatic adenocarcinoma response to chemotherapy enhanced with non-invasive radio frequency evaluated via an integrated experimental/computational approach. Sci Rep 7:3437
Ng, Chin F; Frieboes, Hermann B (2017) Model of vascular desmoplastic multispecies tumor growth. J Theor Biol 430:245-282
Garvey, Colleen M; Gerhart, Torin A; Mumenthaler, Shannon M (2017) Discrimination and Characterization of Heterocellular Populations Using Quantitative Imaging Techniques. J Vis Exp :

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