The long-term goal of the Partnership for Native American Cancer Prevention (NACP) is to eliminate cancer disparities in Native Americans of the southwest. The University of Arizona Cancer Center and Northern Arizona University as NACP, partner with tribal communities to develop research, outreach, and training activities aimed at defining and eliminating obstacles to health equity in areas of Native American cancer incidence, mortality, survivorship, and representation. Expected outcomes include: an increase in the numbers and relevance of cancer-related research projects addressing disparities in cancer among Native Americans of the southwestern US;an increase in the number and diversity of researchers at Northern Arizona University working on cancer-related projects;an increase in the number of university - tribal community partnerships focused on cancer outreach and research;an increase in the numbers of Native American and other students moving into graduate and professional programs focused on health disparities.
Aim One : Our Research and Development Core will foster and support culturally-appropriate research capacity at our institutions both through research projects and through faculty recruitment and development.
Aim Two : We will honor the culture of the Native American communities we serve by providing opportunities to integrate their values, beliefs and needs into every aspect of the NACP.
Aim Three : We will increase the number of culturally competent biomedical researchers and health workers by increasing the number of students, postdocs, and faculty (especially Native Americans) trained in cancer prevention, cancer control, and cancer-related health care policy through our Training Core. NACP has three cancer research projects;(1) Physical activity and cancer among Native American cancer survivors, (2) Functional genetic variants as modifiers of prostate cancer progression in Native Americans and (3) Microbes, bile acids and colorectal cancer.
We propose to use the Three Cores (listed above) of NACP to create respectful and effective interactions among the UACC, NAU and the Native American communities we serve to further build the capacity for culturally-sensitive and community-relevant research on cancer, and to act as brokers between tribal communities, and federal and state agencies so that these sovereign tribal communities can be further empowered to define, implement, and achieve their defined goals of health equity.
|Purohit, Rahul; Fritz, Bradley G; The, Juliana et al. (2014) YC-1 binding to the * subunit of soluble guanylyl cyclase overcomes allosteric inhibition by the * subunit. Biochemistry 53:101-14|
|Gustafson, Heather L; Yao, Song; Goldman, Bryan H et al. (2014) Genetic polymorphisms in oxidative stress-related genes are associated with outcomes following treatment for aggressive B-cell non-Hodgkin lymphoma. Am J Hematol 89:639-45|
|Karn, Robert C; Laukaitis, Christina M (2014) Selection shaped the evolution of mouse androgen-binding protein (ABP) function and promoted the duplication of Abp genes. Biochem Soc Trans 42:851-60|
|Briehl, Margaret M; Tome, Margaret E; Wilkinson, Sarah T et al. (2014) Mitochondria and redox homoeostasis as chemotherapeutic targets. Biochem Soc Trans 42:939-44|
|Janousek, Vaclav; Karn, Robert C; Laukaitis, Christina M (2013) The role of retrotransposons in gene family expansions: insights from the mouse Abp gene family. BMC Evol Biol 13:107|
|Nelson-Moseke, Anna C; Jeter, Joanne M; Cui, Haiyan et al. (2013) An unusual BRCA mutation distribution in a high risk cancer genetics clinic. Fam Cancer 12:83-7|
|Ramanathan, Saumya; Mazzalupo, Stacy; Boitano, Scott et al. (2011) Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration. Biochemistry 50:7787-99|