The Administration, Evaluation and Planning Core (Core A;Dr. Robert Clarke, Core Director) is critical to the success of this CCSB. The primary purpose of Core A is to coordinate CCSB activifies and to provide the oversight and leadership of all scientific, educafional, administrafive, financial, and planning aspects of the CCSB. Activifies within Core A will ensure the full integrafion of the various scientific disciplines into the multidisciplinary approaches we propose for advancing research in the field of cancer systems biology, and its ultimate translation into the clinical setfing. More broadly, the administrafive funcfions are responsible for ensuring compliance with all general, institutional, federal, and NCI/ICBP requirements and regulafions, which include the fimely and effective coordination of communication and consultation within the CCSB, with the appropriate NCI/ICBP staff, the ICBP Steering Committee, and with all other ICBP CCSBs. Core A is also responsible for convening all meetings of the CCSB including those of the Internal Advisory Committee (lAC; membership and functions described below) and External Advisory Committee (EAC).

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
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Special Emphasis Panel (ZCA1-SRLB-C)
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Georgetown University
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Cook, Katherine L; Soto-Pantoja, David R; Clarke, Pamela A G et al. (2016) Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer. Cancer Res 76:5657-5670
Cook, Katherine L; Schwartz-Roberts, Jessica L; Baumann, William T et al. (2016) Linking autophagy with inflammation through IRF1 signaling in ER+ breast cancer. Mol Cell Oncol 3:e1023928
Bhuvaneshwar, Krithika; Belouali, Anas; Singh, Varun et al. (2016) G-DOC Plus - an integrative bioinformatics platform for precision medicine. BMC Bioinformatics 17:193
(2016) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 12:1-222
Chen, Xi; Jung, Jin-Gyoung; Shajahan-Haq, Ayesha N et al. (2016) ChIP-BIT: Bayesian inference of target genes using a novel joint probabilistic model of ChIP-seq profiles. Nucleic Acids Res 44:e65
Beck, Tim N; Korobeynikov, Vladislav A; Kudinov, Alexander E et al. (2016) Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer. Cell Rep 16:657-71
Zhang, Y-W; Nasto, R E; Varghese, R et al. (2016) Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation. Oncogene 35:1643-56
Bhuvaneshwar, Krithika; Sulakhe, Dinanath; Gauba, Robinder et al. (2015) A case study for cloud based high throughput analysis of NGS data using the globus genomics system. Comput Struct Biotechnol J 13:64-74
Shi, Xu; Barnes, Robert O; Chen, Li et al. (2015) BMRF-Net: a software tool for identification of protein interaction subnetworks by a bagging Markov random field-based method. Bioinformatics 31:2412-4
Dabydeen, Sarah A; Kang, Keunsoo; Díaz-Cruz, Edgar S et al. (2015) Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis 36:122-32

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