A highly effective administrative resource is critically important in the successful establishment of this CSMCaD. This core will be the administrative center of the Methodist-Baylor-UTHSC team. The administrative core resource will consist of the Pl. the Core Pis, a Research Project Coordinator and an Administrative Assistant. The CSMCaD advisory committee will communicate directly with this resource in terms of monitoring progress, providing evaluation and counseling the Pl in issues arising during the administration of the Center. The administrative core resource will coordinate the administration of the CSMCaD. organize the steering and advisory committee meetings, and track milestones and project progress. Retreats, symposia, seminars, and meetings will be coordinated and organized through this resource. Monitoring and reconciliation of the various budgets, and facilitation of the purchase of supplies will be also be provided by this resource. The CSMCaD project team consists of seventeen investigators spread over three institutions. Efficient communication and a high level of interaction will be achieved through the administrative resource which will include the maintenance of an interactive Wiki project web site and annual all-hands meetings. Furthermore, email listings where daily postings on day-to-day activities and information will be provided. The administration core will also have support from TMHRI administration resources. Under the direction of Edward Jones, M.B.A., Vice-President in charge of administration, TMHRI has a fully developed and staffed research administration and support infrastructure. Among its innovations is web-based management of the document flow for the Institutional Review Board and other research administration functions. TMHRI is fully compliant with all NIH Grants Policies and OHRP policies regarding human research subjects. The administration core will ensure synergies and resource sharing of Component 1 &Component 2. The weekly meeting between these two components will take place as usual. The core will also make sure management of component 3 -the Education &Training is going well, see details in Section N5.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Specialized Center--Cooperative Agreements (U54)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-SRLB-C)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Methodist Hospital Research Institute
United States
Zip Code
Holloway, Kimberly R; Sinha, Vidya C; Bu, Wen et al. (2016) Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype. Int J Biol Sci 12:381-8
Zhao, Zhen; Zhu, Xiaoping; Cui, Kemi et al. (2016) In Vivo Visualization and Characterization of Epithelial-Mesenchymal Transition in Breast Tumors. Cancer Res 76:2094-104
Hein, S M; Haricharan, S; Johnston, A N et al. (2016) Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress. Oncogene 35:1461-7
Liang, Diana H; Choi, Dong Soon; Ensor, Joe E et al. (2016) The autophagy inhibitor chloroquine targets cancer stem cells in triple negative breast cancer by inducing mitochondrial damage and impairing DNA break repair. Cancer Lett 376:249-58
Yeung, Tsz-Lun; Leung, Cecilia S; Li, Fuhai et al. (2016) Targeting Stromal-Cancer Cell Crosstalk Networks in Ovarian Cancer Treatment. Biomolecules 6:3
Hosoya, Hitomi; Dobroff, Andrey S; Driessen, Wouter H P et al. (2016) Integrated nanotechnology platform for tumor-targeted multimodal imaging and therapeutic cargo release. Proc Natl Acad Sci U S A 113:1877-82
Tanei, Tomonori; Choi, Dong Soon; Rodriguez, Angel A et al. (2016) Antitumor activity of Cetuximab in combination with Ixabepilone on triple negative breast cancer stem cells. Breast Cancer Res 18:6
Park, Jun Hyoung; Vithayathil, Sajna; Kumar, Santosh et al. (2016) Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming and Oncogenic Properties in Triple-Negative Breast Cancer. Cell Rep 14:2154-65
Holloway, Kimberly R; Sinha, Vidya C; Toneff, Michael J et al. (2015) Krt6a-positive mammary epithelial progenitors are not at increased vulnerability to tumorigenesis initiated by ErbB2. PLoS One 10:e0117239
Granados-Principal, Sergio; Liu, Yi; Guevara, Maria L et al. (2015) Inhibition of iNOS as a novel effective targeted therapy against triple-negative breast cancer. Breast Cancer Res 17:25

Showing the most recent 10 out of 92 publications